Geographic range expansion of tetrodotoxin in amphibians : First record in Atelopus hoogmoedi from the Guiana Shield

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2018
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Mebs, Dietrich
Lorentz, Max
Yotsu-Yamashita, Mari
Ernst, Raffael
Lötters, Stefan
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Zusammenfassung

For the first time, alcohol extracts of Atelopus hoogmoedi from the Guiana Shield in Suriname and Guyana were analyzed for the presence of tetrodotoxin (TTX) and of its analogues by high resolution hydrophilic interaction liquid chromatography/mass spectrometry. One specimen from Suriname was found to contain TTX and 4-epiTTX. Using a monoclonal antibody-based immunohistochemical staining technique, TTX was localized mainly in the granular glands and epithelium of the skin, but not in internal organs except liver showing weak TTX-positive reaction. In two specimens collected in Guyana, none of the toxins were detected.

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570 Biowissenschaften, Biologie
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Atelopus hoogmoedi, Tetrodotoxin, Tissue distribution, Monoclonal antibody, Guiana Shield
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ISO 690MEBS, Dietrich, Max LORENTZ, Mari YOTSU-YAMASHITA, Daniela C. RÖSSLER, Raffael ERNST, Stefan LÖTTERS, 2018. Geographic range expansion of tetrodotoxin in amphibians : First record in Atelopus hoogmoedi from the Guiana Shield. In: Toxicon. Elsevier. 2018, 150, pp. 175-179. ISSN 0041-0101. eISSN 1879-3150. Available under: doi: 10.1016/j.toxicon.2018.05.011
BibTex
@article{Mebs2018Geogr-54345,
  year={2018},
  doi={10.1016/j.toxicon.2018.05.011},
  title={Geographic range expansion of tetrodotoxin in amphibians : First record in Atelopus hoogmoedi from the Guiana Shield},
  volume={150},
  issn={0041-0101},
  journal={Toxicon},
  pages={175--179},
  author={Mebs, Dietrich and Lorentz, Max and Yotsu-Yamashita, Mari and Rößler, Daniela C. and Ernst, Raffael and Lötters, Stefan}
}
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