New Approaches to Control Infections : Anti-biofilm Strategies against Gram-negative Bacteria

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CHIMIA : International Journal for Chemistry. 2013, 67(4), pp. 286-290. ISSN 0009-4293. Available under: doi: 10.2533/chimia.2013.286
Zusammenfassung

Hospital-acquired bacterial infections, especially with Gram-negative pathogens, present a major threat due to the rapid spread of antibiotic-resistant strains. Targeting mechanisms of bacterial virulence has recently appeared as a promising new therapeutic paradigm. Biofilm formation is a bacterial lifestyle, which offers a survival advantage through its protective matrix against host immune defense and antibiotic treatment. Interfering with biogenesis of adhesive organelles, bacterial communication or carbohydrate-mediated adhesion as anti-biofilm strategies are reviewed.

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ISO 690SOMMER, Roman, Ines JOACHIM, Stefanie WAGNER, Alexander TITZ, 2013. New Approaches to Control Infections : Anti-biofilm Strategies against Gram-negative Bacteria. In: CHIMIA : International Journal for Chemistry. 2013, 67(4), pp. 286-290. ISSN 0009-4293. Available under: doi: 10.2533/chimia.2013.286
BibTex
@article{Sommer2013-04-24Appro-41909,
  year={2013},
  doi={10.2533/chimia.2013.286},
  title={New Approaches to Control Infections : Anti-biofilm Strategies against Gram-negative Bacteria},
  number={4},
  volume={67},
  issn={0009-4293},
  journal={CHIMIA : International Journal for Chemistry},
  pages={286--290},
  author={Sommer, Roman and Joachim, Ines and Wagner, Stefanie and Titz, Alexander}
}
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