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Safer chemicals using less animals : kick-off of the European ONTOX project

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2021

Autor:innen

Vinken, Mathieu
Benfenati, Emilio
Busquet, François
Castell, José
Clevert, Djork-Arné
de Kok, Theo M.
Dirven, Hubert
Fritsche, Ellen
Geris, Liesbet
et al.

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European Union (EU): 963845

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Open Access-Veröffentlichung
Core Facility der Universität Konstanz

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Published

Erschienen in

Toxicology. Elsevier. 2021, 458, 152846. ISSN 0300-483X. eISSN 1879-3185. Available under: doi: 10.1016/j.tox.2021.152846

Zusammenfassung

The 3Rs concept, calling for replacement, reduction and refinement of animal experimentation, is receiving increasing attention around the world, and has found its way to legislation, in particular in the European Union. This is aligned by continuing high-level efforts of the European Commission to support development and implementation of 3Rs methods. In this respect, the European project called "ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment" was recently initiated with the goal to provide a functional and sustainable solution for advancing human risk assessment of chemicals without the use of animals in line with the principles of 21st century toxicity testing and next generation risk assessment. ONTOX will deliver a generic strategy to create new approach methodologies (NAMs) in order to predict systemic repeated dose toxicity effects that, upon combination with tailored exposure assessment, will enable human risk assessment. For proof-of-concept purposes, focus is put on NAMs addressing adversities in the liver, kidneys and developing brain induced by a variety of chemicals. The NAMs each consist of a computational system based on artificial intelligence and are fed by biological, toxicological, chemical and kinetic data. Data are consecutively integrated in physiological maps, quantitative adverse outcome pathway networks and ontology frameworks. Supported by artificial intelligence, data gaps are identified and are filled by targeted in vitro and in silico testing. ONTOX is anticipated to have a deep and long-lasting impact at many levels, in particular by consolidating Europe's world-leading position regarding the development, exploitation, regulation and application of animal-free methods for human risk assessment of chemicals.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

ONTOX, European project, 3Rs, In vitro, In silico, Systemic toxicity, Ontology, Artificial intelligence

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ISO 690VINKEN, Mathieu, Emilio BENFENATI, François BUSQUET, José CASTELL, Djork-Arné CLEVERT, Theo M. DE KOK, Hubert DIRVEN, Ellen FRITSCHE, Liesbet GERIS, Thomas HARTUNG, 2021. Safer chemicals using less animals : kick-off of the European ONTOX project. In: Toxicology. Elsevier. 2021, 458, 152846. ISSN 0300-483X. eISSN 1879-3185. Available under: doi: 10.1016/j.tox.2021.152846
BibTex
@article{Vinken2021Safer-54571,
  year={2021},
  doi={10.1016/j.tox.2021.152846},
  title={Safer chemicals using less animals : kick-off of the European ONTOX project},
  volume={458},
  issn={0300-483X},
  journal={Toxicology},
  author={Vinken, Mathieu and Benfenati, Emilio and Busquet, François and Castell, José and Clevert, Djork-Arné and de Kok, Theo M. and Dirven, Hubert and Fritsche, Ellen and Geris, Liesbet and Hartung, Thomas},
  note={Article Number: 152846}
}
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