Publikation: Similarities and differences between fish oligodendrocytes and schwann cells in vitro
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n light of the striking differences between oligodendrocytes of the optic nerve/tract of adult goldfish and their mammalian counterparts, a further characterization of goldfish oligodendrocytes was performed. A comparison with Schwann cells was included because fish optic nerve/tract-derived oligodendrocytes bear remarkable similarities to this type of glial cell. Fish optic nerve/tract-derived oligodendrocytes that had differentiated into 04 and 6D2-positive cells and thus expressed early myelin marker molecules were found to incorporate BrdU and to divide in vitro over a period of weeks. For the induction of more advanced markers of myelinogenesis such as the CNS-specific myelin protein 36K, oligodendrocytes required extensive contact with axons. Other agents, such as fetal calf or carp serum, substrate components, or forscolin failed, however, to induce 36K expression. 04/6D2-positive oligodendrocytes could be distinguished from fish 6D2-positive Schwann cells derived from cranial nerves by their antigenic pheno-type: Schwann cells but not oligodendrocytes exhibited the low affinity NGF receptor. While both cell types carry the cell adhesion molecules NCAM, E 587 antigen, and the L2/HNK-1 epitope, only Schwann cells possess a further adhesion molecule, Neurolin.
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BASTMEYER, Martin, Gunnar JESERICH, Claudia STÜRMER, 1994. Similarities and differences between fish oligodendrocytes and schwann cells in vitro. In: Glia. 1994, 11(4), pp. 300-314. ISSN 0894-1491. eISSN 1098-1136. Available under: doi: 10.1002/glia.440110403BibTex
@article{Bastmeyer1994Simil-7350, year={1994}, doi={10.1002/glia.440110403}, title={Similarities and differences between fish oligodendrocytes and schwann cells in vitro}, number={4}, volume={11}, issn={0894-1491}, journal={Glia}, pages={300--314}, author={Bastmeyer, Martin and Jeserich, Gunnar and Stürmer, Claudia} }
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