EPR imaging of magnetic field effects on radiation dose distributions around millimeter-size air cavities

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2019
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Fix, Michael K.
Zwicker, Felix
Sterpin, Edmond
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Physics in Medicine & Biology. 2019, 64(17), 175013. ISSN 0031-9155. eISSN 1361-6560. Available under: doi: 10.1088/1361-6560/ab325b
Zusammenfassung

New hybrid radiotherapy treatment systems combining an MRI scanner with a source of ionizing radiation are being introduced in the clinic. The strong magnetic fields of MRI considerably affect radiation dose distributions, especially at tissue-air interfaces due to the electron return effect (ERE). Experimental investigation of the ERE within a sub-millimeter thick surface layer is still highly challenging.

In the present work, we examine and quantify the magnetic field induced perturbations of dose distributions within a 0.5 mm layer surrounding millimeter-size air cavities by applying electron paramagnetic resonance imaging (EPRI).

Air-filled fused quartz tubes (inner diameter 3 or 4 mm) mimic small air cavities and serve as model systems. The tubes were irradiated inside a PMMA phantom by a 6 MV photon beam. The irradiations were performed in the presence or absence of a transverse, magnetic field providing a magnetic field strength of 1.0 Tesla. The spatial distributions of radiation induced paramagnetic defects in the quartz tubes were subsequently determined by applying field-swept echo-detected EPRI and were then converted to relative dose distributions.

The transverse magnetic field leads to considerable local dose enhancements and reductions (up to 35%) with respect to the mean dose within the quartz tubes. The experimentally determined dose distributions are in good quantitative agreement with Monte Carlo radiation transport simulations.

The results of this work demonstrate the feasibility of field-swept echo-detected EPRI to measure magnetic field induced perturbations of dose distributions within a sub-millimeter thick surface layer at the dosimeter-air interface.

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Fachgebiet (DDC)
540 Chemie
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EPR imaging, radiotherapy, MR-linac, MRgRT, irradiated quartz, dosimetry
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ISO 690HÖFEL, Sebastian, Michael K. FIX, Felix ZWICKER, Edmond STERPIN, Malte DRESCHER, 2019. EPR imaging of magnetic field effects on radiation dose distributions around millimeter-size air cavities. In: Physics in Medicine & Biology. 2019, 64(17), 175013. ISSN 0031-9155. eISSN 1361-6560. Available under: doi: 10.1088/1361-6560/ab325b
BibTex
@article{Hofel2019-09-04imagi-47016,
  year={2019},
  doi={10.1088/1361-6560/ab325b},
  title={EPR imaging of magnetic field effects on radiation dose distributions around millimeter-size air cavities},
  number={17},
  volume={64},
  issn={0031-9155},
  journal={Physics in Medicine & Biology},
  author={Höfel, Sebastian and Fix, Michael K. and Zwicker, Felix and Sterpin, Edmond and Drescher, Malte},
  note={Article Number: 175013}
}
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    <dcterms:abstract xml:lang="eng">New hybrid radiotherapy treatment systems combining an MRI scanner with a source of ionizing radiation are being introduced in the clinic. The strong magnetic fields of MRI considerably affect radiation dose distributions, especially at tissue-air interfaces due to the electron return effect (ERE). Experimental investigation of the ERE within a sub-millimeter thick surface layer is still highly challenging.&lt;br /&gt;&lt;br /&gt;In the present work, we examine and quantify the magnetic field induced perturbations of dose distributions within a 0.5 mm layer surrounding millimeter-size air cavities by applying electron paramagnetic resonance imaging (EPRI).&lt;br /&gt;&lt;br /&gt;Air-filled fused quartz tubes (inner diameter 3 or 4 mm) mimic small air cavities and serve as model systems. The tubes were irradiated inside a PMMA phantom by a 6 MV photon beam. The irradiations were performed in the presence or absence of a transverse, magnetic field providing a magnetic field strength of 1.0 Tesla. The spatial distributions of radiation induced paramagnetic defects in the quartz tubes were subsequently determined by applying field-swept echo-detected EPRI and were then converted to relative dose distributions.&lt;br /&gt;&lt;br /&gt;The transverse magnetic field leads to considerable local dose enhancements and reductions (up to 35%) with respect to the mean dose within the quartz tubes. The experimentally determined dose distributions are in good quantitative agreement with Monte Carlo radiation transport simulations.&lt;br /&gt;&lt;br /&gt;The results of this work demonstrate the feasibility of field-swept echo-detected EPRI to measure magnetic field induced perturbations of dose distributions within a sub-millimeter thick surface layer at the dosimeter-air interface.</dcterms:abstract>
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