Publikation:

Phage Display Screening as a Rational Approach to Design Additives for Selective Crystallization Control in Construction Systems

Lade...
Vorschaubild

Dateien

Madeja_2-1a0dj211fpdsk1.PDF
Madeja_2-1a0dj211fpdsk1.PDFGröße: 1.42 MBDownloads: 30

Datum

2023

Autor:innen

Wilke, Patrick
Schreiner, Eduard
Konradi, Rupert
Bizzozero, Julien
Nicoleau, Luc
Wagner, Elisabeth
et al.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
oops

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Hybrid
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Advanced Materials. Wiley. 2023, 35(20), 2210015. ISSN 0935-9648. eISSN 1521-4095. Verfügbar unter: doi: 10.1002/adma.202210015

Zusammenfassung

The design of additives showing strong and selective interactions with certain target surfaces is key to crystallization control in applied reactive multicomponent systems. While suitable chemical motifs can be found through semi-empirical trial-and-error procedures, bioinspired selection techniques offer a more rationally driven approach and explore a much larger space of possible combinations in a single assay. Here we use phage display screening to characterize the surfaces of crystalline gypsum, a mineral of broad relevance for construction applications. Based on next-generation sequencing of phages enriched during the screening process, we identify a triplet of amino acids, DYH, as main driver for adsorption on the mineral substrate. Furthermore, oligopeptides containing this motif prove to exert their influence in a strictly selective manner during the hydration of cements, where the sulfate reaction (initial setting) is strongly retarded while the silicate reaction (final hardening) remains unaffected. In a final step, these desired additive characteristics are successfully translated from the level of peptides to that of scalable synthetic copolymers. The approach described in this work demonstrates how modern biotechnological methods can be leveraged for the systematic development of efficient crystallization additives for materials science.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690MADEJA, Benjamin, Patrick WILKE, Eduard SCHREINER, Rupert KONRADI, Johanna SCHECK, Julien BIZZOZERO, Luc NICOLEAU, Elisabeth WAGNER, Helmut CÖLFEN, Matthias KELLERMEIER, 2023. Phage Display Screening as a Rational Approach to Design Additives for Selective Crystallization Control in Construction Systems. In: Advanced Materials. Wiley. 2023, 35(20), 2210015. ISSN 0935-9648. eISSN 1521-4095. Verfügbar unter: doi: 10.1002/adma.202210015
BibTex
@article{Madeja2023Phage-66415,
  year={2023},
  doi={10.1002/adma.202210015},
  title={Phage Display Screening as a Rational Approach to Design Additives for Selective Crystallization Control in Construction Systems},
  number={20},
  volume={35},
  issn={0935-9648},
  journal={Advanced Materials},
  author={Madeja, Benjamin and Wilke, Patrick and Schreiner, Eduard and Konradi, Rupert and Scheck, Johanna and Bizzozero, Julien and Nicoleau, Luc and Wagner, Elisabeth and Cölfen, Helmut and Kellermeier, Matthias},
  note={Article Number: 2210015}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/66415">
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-03-15T13:34:26Z</dcterms:available>
    <dc:creator>Konradi, Rupert</dc:creator>
    <dc:creator>Cölfen, Helmut</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Schreiner, Eduard</dc:creator>
    <dc:contributor>Bizzozero, Julien</dc:contributor>
    <dc:creator>Kellermeier, Matthias</dc:creator>
    <dc:contributor>Cölfen, Helmut</dc:contributor>
    <dc:contributor>Schreiner, Eduard</dc:contributor>
    <dc:creator>Scheck, Johanna</dc:creator>
    <dcterms:abstract>The design of additives showing strong and selective interactions with certain target surfaces is key to crystallization control in applied reactive multicomponent systems. While suitable chemical motifs can be found through semi-empirical trial-and-error procedures, bioinspired selection techniques offer a more rationally driven approach and explore a much larger space of possible combinations in a single assay. Here we use phage display screening to characterize the surfaces of crystalline gypsum, a mineral of broad relevance for construction applications. Based on next-generation sequencing of phages enriched during the screening process, we identify a triplet of amino acids, DYH, as main driver for adsorption on the mineral substrate. Furthermore, oligopeptides containing this motif prove to exert their influence in a strictly selective manner during the hydration of cements, where the sulfate reaction (initial setting) is strongly retarded while the silicate reaction (final hardening) remains unaffected. In a final step, these desired additive characteristics are successfully translated from the level of peptides to that of scalable synthetic copolymers. The approach described in this work demonstrates how modern biotechnological methods can be leveraged for the systematic development of efficient crystallization additives for materials science.</dcterms:abstract>
    <dc:creator>Bizzozero, Julien</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:creator>Madeja, Benjamin</dc:creator>
    <dc:language>eng</dc:language>
    <dcterms:title>Phage Display Screening as a Rational Approach to Design Additives for Selective Crystallization Control in Construction Systems</dcterms:title>
    <dc:contributor>Wagner, Elisabeth</dc:contributor>
    <dc:contributor>Wilke, Patrick</dc:contributor>
    <dcterms:issued>2023</dcterms:issued>
    <dc:contributor>Nicoleau, Luc</dc:contributor>
    <dc:creator>Wagner, Elisabeth</dc:creator>
    <dc:creator>Wilke, Patrick</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/66415/1/Madeja_2-1a0dj211fpdsk1.PDF"/>
    <dc:contributor>Kellermeier, Matthias</dc:contributor>
    <dc:contributor>Scheck, Johanna</dc:contributor>
    <dc:contributor>Konradi, Rupert</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/66415"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/66415/1/Madeja_2-1a0dj211fpdsk1.PDF"/>
    <dc:contributor>Madeja, Benjamin</dc:contributor>
    <dc:creator>Nicoleau, Luc</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-03-15T13:34:26Z</dc:date>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen