Publikation:

Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells

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Waeckerle-Men_221179.pdf
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Datum

2006

Autor:innen

Waeckerle-Men, Ying
Gander, Bruno
Scandella, Elke
Merkle, Hans P.

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-221179
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.vaccine.2005.10.032
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Biologie: Publikationen
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Published

Erschienen in

Vaccine. 2006, 24(11), pp. 1847-1857. ISSN 0264-410X. eISSN 1873-2518. Available under: doi: 10.1016/j.vaccine.2005.10.032

Zusammenfassung

Dendritic cell (DC)-based immunotherapy has been hampered by the lack of suitable methods for antigen delivery. Here, we use biodegradable poly(d,l-lactide-co-glycolide) microspheres (PLGA-MS) as carriers of peptides and proteins for antigen delivery to human monocyte-derived DC (MoDC). Compared to soluble proteins, MHC classes I and II-restricted presentation of PLGA-MS-encapsulated proteins and peptides by MoDC was markedly prolonged and proteins were presented 50-fold more efficiently on class I molecules. The vaccination of mice with DC loaded with PLGA-MS-encapsulated proteins raised strong and persisting cytotoxic T cell responses. In conclusion, antigen delivery via PLGA-MS markedly enhanced the duration of antigen presentation by human MoDC and the potency of DC-based vaccination.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

PLGA microspheres, Dendritic cells, Antigen delivery, Antigen presentation

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ISO 690WAECKERLE-MEN, Ying, Edith UETZ-VON ALLMEN, Bruno GANDER, Elke SCANDELLA, Eva SCHLOSSER, Gunter SCHMIDTKE, Hans P. MERKLE, Marcus GRÖTTRUP, 2006. Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells. In: Vaccine. 2006, 24(11), pp. 1847-1857. ISSN 0264-410X. eISSN 1873-2518. Available under: doi: 10.1016/j.vaccine.2005.10.032
BibTex
@article{WaeckerleMen2006-03-10Encap-22117,
  year={2006},
  doi={10.1016/j.vaccine.2005.10.032},
  title={Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells},
  number={11},
  volume={24},
  issn={0264-410X},
  journal={Vaccine},
  pages={1847--1857},
  author={Waeckerle-Men, Ying and Uetz-von Allmen, Edith and Gander, Bruno and Scandella, Elke and Schlosser, Eva and Schmidtke, Gunter and Merkle, Hans P. and Gröttrup, Marcus}
}
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