@article{Fallah2017-12-05Simul-40331,
  year={2017},
  doi={10.1002/cbic.201700355},
  title={Simultaneous IR-spectroscopic observation of α-synuclein, lipids, and solvent reveals an alternative membrane-induced oligomerization pathway},
  number={23},
  volume={18},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={2312--2316},
  author={Fallah, Mohammad A. and Gerding, Hanne R. and Scheibe, Christian and Drescher, Malte and Karreman, Christiaan and Schildknecht, Stefan and Leist, Marcel and Hauser, Karin}
}

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/40331">
    <dc:contributor>Hauser, Karin</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-10-13T11:26:09Z</dcterms:available>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Karreman, Christiaan</dc:contributor>
    <dcterms:abstract xml:lang="eng">The intrinsically disordered protein α-synuclein (αS), a known pathogenic factor for Parkinson's disease, can adopt defined secondary structures when interacting with membranes or during fibrillation. The αS-lipid interaction and the implications of this process for aggregation and damage to membranes are still poorly understood. Therefore, we established a label-free infrared (IR) spectroscopic approach to simultaneously monitor αS conformation and membrane integrity. IR showed its unique sensitivity for identifying distinct α-structured aggregates. A comparative study of wildtype αS and the naturally occurring splicing variant αS Δexon3 yielded new insights into the membrane's capability of altering aggregation pathways.</dcterms:abstract>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-10-13T11:26:09Z</dc:date>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40331/1/Fallah_2-1eodq8f5g6c7y3.pdf"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40331/1/Fallah_2-1eodq8f5g6c7y3.pdf"/>
    <dc:creator>Karreman, Christiaan</dc:creator>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <dc:contributor>Fallah, Mohammad A.</dc:contributor>
    <dc:creator>Fallah, Mohammad A.</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/40331"/>
    <dc:creator>Leist, Marcel</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Scheibe, Christian</dc:creator>
    <dc:creator>Schildknecht, Stefan</dc:creator>
    <dc:contributor>Drescher, Malte</dc:contributor>
    <dc:creator>Drescher, Malte</dc:creator>
    <dc:contributor>Gerding, Hanne R.</dc:contributor>
    <dc:creator>Gerding, Hanne R.</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:title>Simultaneous IR-spectroscopic observation of α-synuclein, lipids, and solvent reveals an alternative membrane-induced oligomerization pathway</dcterms:title>
    <dcterms:issued>2017-12-05</dcterms:issued>
    <dc:creator>Hauser, Karin</dc:creator>
    <dc:contributor>Schildknecht, Stefan</dc:contributor>
    <dc:language>eng</dc:language>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Scheibe, Christian</dc:contributor>
  </rdf:Description>
</rdf:RDF>