Publikation:

Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering

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Hardy_0-372725.pdf
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Datum

2016

Autor:innen

Hardy, John G.
Torres-Rendon, Jose Guillermo
Leal-Egaña, Aldo
Walther, Andreas
Schlaad, Helmut
Scheibel, Thomas R.

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-0-372725
DOI (zitierfähiger Link)
https://doi.org/10.3390/ma9070560
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CC BY 4.0

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Open Access-Veröffentlichung
Open Access Gold

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Chemie: Publikationen
Core Facility der Universität Konstanz

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Zeitschriftenartikel
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Published

Erschienen in

Materials. 2016, 9(7), 560. eISSN 1996-1944. Available under: doi: 10.3390/ma9070560

Zusammenfassung

Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue Engineering.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

Schlagwörter

spider silk; recombinant protein; biodegradable polymers; biomaterials; biomineralization; bone tissue engineering

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ISO 690HARDY, John G., Jose Guillermo TORRES-RENDON, Aldo LEAL-EGAÑA, Andreas WALTHER, Helmut SCHLAAD, Helmut CÖLFEN, Thomas R. SCHEIBEL, 2016. Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering. In: Materials. 2016, 9(7), 560. eISSN 1996-1944. Available under: doi: 10.3390/ma9070560
BibTex
@article{Hardy2016-07-11Biomi-35921,
  year={2016},
  doi={10.3390/ma9070560},
  title={Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering},
  number={7},
  volume={9},
  journal={Materials},
  author={Hardy, John G. and Torres-Rendon, Jose Guillermo and Leal-Egaña, Aldo and Walther, Andreas and Schlaad, Helmut and Cölfen, Helmut and Scheibel, Thomas R.},
  note={Article Number: 560}
}
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