Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering

Kurzanzeige
dc.contributor.authorHardy, John G.
dc.contributor.authorTorres-Rendon, Jose Guillermo
dc.contributor.authorLeal-Egaña, Aldo
dc.contributor.authorWalther, Andreas
dc.contributor.authorSchlaad, Helmut
dc.contributor.authorCölfen, Helmut
dc.contributor.authorScheibel, Thomas R.
dc.date.accessioned2016-11-15T14:05:16Z
dc.date.available2016-11-15T14:05:16Z
dc.date.issued2016-07-11eng
dc.description.abstractMaterials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue Engineering.eng
dc.description.versionpublishedeng
dc.identifier.doi10.3390/ma9070560eng
dc.identifier.ppn479771820
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/35921
dc.language.isoengeng
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectspider silk; recombinant protein; biodegradable polymers; biomaterials; biomineralization; bone tissue engineeringeng
dc.subject.ddc540eng
dc.titleBiomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineeringeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Hardy2016-07-11Biomi-35921,
  year={2016},
  doi={10.3390/ma9070560},
  title={Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering},
  number={7},
  volume={9},
  journal={Materials},
  author={Hardy, John G. and Torres-Rendon, Jose Guillermo and Leal-Egaña, Aldo and Walther, Andreas and Schlaad, Helmut and Cölfen, Helmut and Scheibel, Thomas R.},
  note={Article Number: 560}
}
kops.citation.iso690HARDY, John G., Jose Guillermo TORRES-RENDON, Aldo LEAL-EGAÑA, Andreas WALTHER, Helmut SCHLAAD, Helmut CÖLFEN, Thomas R. SCHEIBEL, 2016. Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering. In: Materials. 2016, 9(7), 560. eISSN 1996-1944. Available under: doi: 10.3390/ma9070560deu
kops.citation.iso690HARDY, John G., Jose Guillermo TORRES-RENDON, Aldo LEAL-EGAÑA, Andreas WALTHER, Helmut SCHLAAD, Helmut CÖLFEN, Thomas R. SCHEIBEL, 2016. Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering. In: Materials. 2016, 9(7), 560. eISSN 1996-1944. Available under: doi: 10.3390/ma9070560eng
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