Acetylene Hydratase
| dc.contributor.author | Seiffert, Grazyna B | |
| dc.contributor.author | Abt, Dietmar | |
| dc.contributor.author | tenBrink, Felix | |
| dc.contributor.author | Fischer, David | |
| dc.contributor.author | Einsle, Oliver | |
| dc.contributor.author | Kroneck, Peter M. H. | |
| dc.date.accessioned | 2017-06-01T09:29:50Z | |
| dc.date.available | 2017-06-01T09:29:50Z | |
| dc.date.issued | 2011 | eng |
| dc.description.abstract | The tungsten-iron-sulfur enzyme acetylene hydratase is a rather unique enzyme within the class of tungsten/molybdenum enzymes in the sense that it catalyzes a nonredox reaction, the addition of one molecule of water to the C[TRIPLE BOND]C bond of acetylene to form acetaldehyde. Its crystal structure (1.26 Å) reveals a close to octahedral, or trigonal antiprismatic tungsten center, which binds a water molecule that gets activated by an adjacent aspartate residue such that it can attack an acetylene molecule bound in a distinct, hydrophobic pocket. This requires a strong shift of pKa of the aspartate, caused by a nearby low-potential [4Fe–4S] cluster. To gain access to this novel W-Asp-active site, the protein evolved a new substrate channel distant from where it is found in other molybdenum and tungsten enzymes. | eng |
| dc.description.version | published | eng |
| dc.identifier.doi | 10.1002/9781119951438.eibc0658 | eng |
| dc.identifier.uri | https://kops.uni-konstanz.de/handle/123456789/39101 | |
| dc.language.iso | eng | eng |
| dc.subject.ddc | 570 | eng |
| dc.title | Acetylene Hydratase | eng |
| dc.type | INCOLLECTION | eng |
| dspace.entity.type | Publication | |
| kops.citation.bibtex | @incollection{Seiffert2011Acety-39101,
year={2011},
doi={10.1002/9781119951438.eibc0658},
title={Acetylene Hydratase},
isbn={978-1-119-95143-8},
publisher={John Wiley & Sons, Ltd},
address={Chichester, UK},
booktitle={Encyclopedia of Inorganic and Bioinorganic Chemistry},
editor={Scott, Robert A.},
author={Seiffert, Grazyna B and Abt, Dietmar and tenBrink, Felix and Fischer, David and Einsle, Oliver and Kroneck, Peter M. H.}
} | |
| kops.citation.iso690 | SEIFFERT, Grazyna B, Dietmar ABT, Felix TENBRINK, David FISCHER, Oliver EINSLE, Peter M. H. KRONECK, 2011. Acetylene Hydratase. In: SCOTT, Robert A., ed.. Encyclopedia of Inorganic and Bioinorganic Chemistry. Chichester, UK: John Wiley & Sons, Ltd, 2011. ISBN 978-1-119-95143-8. Available under: doi: 10.1002/9781119951438.eibc0658 | deu |
| kops.citation.iso690 | SEIFFERT, Grazyna B, Dietmar ABT, Felix TENBRINK, David FISCHER, Oliver EINSLE, Peter M. H. KRONECK, 2011. Acetylene Hydratase. In: SCOTT, Robert A., ed.. Encyclopedia of Inorganic and Bioinorganic Chemistry. Chichester, UK: John Wiley & Sons, Ltd, 2011. ISBN 978-1-119-95143-8. Available under: doi: 10.1002/9781119951438.eibc0658 | eng |
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| kops.sourcefield | SCOTT, Robert A., ed.. <i>Encyclopedia of Inorganic and Bioinorganic Chemistry</i>. Chichester, UK: John Wiley & Sons, Ltd, 2011. ISBN 978-1-119-95143-8. Available under: doi: 10.1002/9781119951438.eibc0658 | deu |
| kops.sourcefield.plain | SCOTT, Robert A., ed.. Encyclopedia of Inorganic and Bioinorganic Chemistry. Chichester, UK: John Wiley & Sons, Ltd, 2011. ISBN 978-1-119-95143-8. Available under: doi: 10.1002/9781119951438.eibc0658 | deu |
| kops.sourcefield.plain | SCOTT, Robert A., ed.. Encyclopedia of Inorganic and Bioinorganic Chemistry. Chichester, UK: John Wiley & Sons, Ltd, 2011. ISBN 978-1-119-95143-8. Available under: doi: 10.1002/9781119951438.eibc0658 | eng |
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| source.contributor.editor | Scott, Robert A. | |
| source.identifier.isbn | 978-1-119-95143-8 | eng |
| source.publisher | John Wiley & Sons, Ltd | eng |
| source.publisher.location | Chichester, UK | eng |
| source.title | Encyclopedia of Inorganic and Bioinorganic Chemistry | eng |