Publikation:

Prognostic significance of apoptotic cell death in bladder cancer : a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens

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2010

Autor:innen

Karamitopoulou, Eva
Rentsch, Cyrill A.
Markwalder, Regula
Vallan, Claudio
Thalmann, George N.

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-128479
DOI (zitierfähiger Link)
https://doi.org/10.3109/00313020903434397
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Biologie: Publikationen
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Published

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Pathology. 2010, 42(1), pp. 37-42. ISSN 0031-3025. eISSN 1465-3931. Available under: doi: 10.3109/00313020903434397

Zusammenfassung

Aims: To assess the prognostic significance of apoptosis related markers in bladder cancer.
Methods: A tissue microarray containing 179 bladder carcinomas from cystectomy specimens was analysed immunohistochemically for active caspase-3, single-stranded DNA (ssDNA), p53, Bcl-2, Bax, and COX-2, in correlation to clinicopathological factors.
Results: Active caspase-3, ssDNA, p53, Bax and COX-2 were more frequently observed among high grade and higher stage (!T2) carcinomas compared with low grade and lower stage (T1) tumours. On the contrary, Bcl-2 was more frequently detected in T1 than in !T2 carcinomas. Active caspase-3 correlated with a better survival of the patients.
Conclusions: The decreased detection of active caspase-3 and ssDNA and the increased presence of Bcl-2 in T1 carcinomas suggest that alterations in interrelated apoptosis markers may play an important role in the progression of urothelial carcinoma from a superficially infiltrating to a muscle invading tumour and would help to better characterise a subpopulation of T1 carcinomas that could profit from early cystectomy or more aggressive adjuvant chemotherapy. Active caspase-3 might be an important prognostic factor in bladder cancer.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

apoptosis, active caspase-3, ssDNA, bladder cancer

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ISO 690KARAMITOPOULOU, Eva, Cyrill A. RENTSCH, Regula MARKWALDER, Claudio VALLAN, George N. THALMANN, Thomas BRUNNER, 2010. Prognostic significance of apoptotic cell death in bladder cancer : a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens. In: Pathology. 2010, 42(1), pp. 37-42. ISSN 0031-3025. eISSN 1465-3931. Available under: doi: 10.3109/00313020903434397
BibTex
@article{Karamitopoulou2010Progn-7086,
  year={2010},
  doi={10.3109/00313020903434397},
  title={Prognostic significance of apoptotic cell death in bladder cancer : a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens},
  number={1},
  volume={42},
  issn={0031-3025},
  journal={Pathology},
  pages={37--42},
  author={Karamitopoulou, Eva and Rentsch, Cyrill A. and Markwalder, Regula and Vallan, Claudio and Thalmann, George N. and Brunner, Thomas}
}
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