NAD+ in sulfur mustard toxicity

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2020
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Zusammenfassung

Sulfur mustard (SM) is a toxicant and chemical warfare agent with strong vesicant properties. The mechanisms behind SM-induced toxicity are not fully understood and no antidote or effective therapy against SM exists. Both, the risk of SM release in asymmetric conflicts or terrorist attacks and the usage of SM-derived nitrogen mustards as cancer chemotherapeutics, render the mechanisms of mustard-induced toxicity a highly relevant research subject. Herein, we review a central role of the abundant cellular molecule nicotinamide adenine dinucleotide (NAD+) in molecular mechanisms underlying SM toxicity. We also discuss the potential beneficial effects of NAD+ precursors in counteracting SM-induced damage.

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570 Biowissenschaften, Biologie
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Sulfur mustard, nicotinamide adenine dinucleotide, NAD, cytotoxicity, PARP, sirtuins
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ISO 690RUSZKIEWICZ, Joanna A., Alexander BÜRKLE, Aswin MANGERICH, 2020. NAD+ in sulfur mustard toxicity. In: Toxicology Letters. Elsevier. 2020, 324, pp. 95-103. ISSN 0378-4274. eISSN 1879-3169. Available under: doi: 10.1016/j.toxlet.2020.01.024
BibTex
@article{Ruszkiewicz2020-05sulfu-48516,
  year={2020},
  doi={10.1016/j.toxlet.2020.01.024},
  title={NAD<sup>+</sup> in sulfur mustard toxicity},
  volume={324},
  issn={0378-4274},
  journal={Toxicology Letters},
  pages={95--103},
  author={Ruszkiewicz, Joanna A. and Bürkle, Alexander and Mangerich, Aswin}
}
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