A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis

Kurzanzeige
dc.contributor.authorGisin, Jonathan
dc.contributor.authorSchneider, Alexander
dc.contributor.authorNägele, Bettina
dc.contributor.authorBorisova, Marina
dc.contributor.authorMayer, Christoph
dc.date.accessioned2018-04-17T06:48:45Z
dc.date.available2018-04-17T06:48:45Z
dc.date.issued2013-08eng
dc.description.abstractWe report a salvage pathway in Gram-negative bacteria that bypasses de novo biosynthesis of UDP N-acetylmuramic acid (UDP-MurNAc), the first committed peptidoglycan precursor, and thus provides a rationale for intrinsic fosfomycin resistance. The anomeric sugar kinase AmgK and the MurNAc α-1-phosphate uridylyl transferase MurU, defining this new cell wall sugar-recycling route in Pseudomonas putida, were characterized and engineered into Escherichia coli, channeling external MurNAc directly to peptidoglycan biosynthesis.eng
dc.description.versionpublishedde
dc.identifier.doi10.1038/nchembio.1289eng
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/42053
dc.language.isoengeng
dc.subject.ddc570eng
dc.titleA cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesiseng
dc.typeJOURNAL_ARTICLEde
dspace.entity.typePublication
kops.citation.bibtex
@article{Gisin2013-08recyc-42053,
  year={2013},
  doi={10.1038/nchembio.1289},
  title={A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis},
  number={8},
  volume={9},
  issn={1552-4450},
  journal={Nature Chemical Biology},
  pages={491--493},
  author={Gisin, Jonathan and Schneider, Alexander and Nägele, Bettina and Borisova, Marina and Mayer, Christoph}
}
kops.citation.iso690GISIN, Jonathan, Alexander SCHNEIDER, Bettina NÄGELE, Marina BORISOVA, Christoph MAYER, 2013. A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. In: Nature Chemical Biology. 2013, 9(8), pp. 491-493. ISSN 1552-4450. eISSN 1552-4469. Available under: doi: 10.1038/nchembio.1289deu
kops.citation.iso690GISIN, Jonathan, Alexander SCHNEIDER, Bettina NÄGELE, Marina BORISOVA, Christoph MAYER, 2013. A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. In: Nature Chemical Biology. 2013, 9(8), pp. 491-493. ISSN 1552-4450. eISSN 1552-4469. Available under: doi: 10.1038/nchembio.1289eng
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kops.sourcefieldNature Chemical Biology. 2013, <b>9</b>(8), pp. 491-493. ISSN 1552-4450. eISSN 1552-4469. Available under: doi: 10.1038/nchembio.1289deu
kops.sourcefield.plainNature Chemical Biology. 2013, 9(8), pp. 491-493. ISSN 1552-4450. eISSN 1552-4469. Available under: doi: 10.1038/nchembio.1289deu
kops.sourcefield.plainNature Chemical Biology. 2013, 9(8), pp. 491-493. ISSN 1552-4450. eISSN 1552-4469. Available under: doi: 10.1038/nchembio.1289eng
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