Publikation:

CCR7 : Roles in cancer cell dissemination, migration and metastasis formation

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Legler_0-258852.pdf
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2014

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http://nbn-resolving.de/urn:nbn:de:bsz:352-0-258852
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.biocel.2014.07.002
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Biologie: Publikationen
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The International Journal of Biochemistry & Cell Biology. 2014, 54, pp. 78-82. ISSN 1357-2725. eISSN 1878-5875. Available under: doi: 10.1016/j.biocel.2014.07.002

Zusammenfassung

The CC-chemokine receptor 7 (CCR7) coordinates the migration of cancer cells as well as immune cells towards lymphatic organs where its two ligands CCL19 and CCL21 are constitutively expressed. Here we provide a topological model of CCR7, which belongs to the class A of G-protein coupled, seven-transmembrane spanning receptors, and describe how CCR7 expression is regulated. We focus on its role in cancer cell migration and metastasis formation and discuss how cancer cells can utilize CCR7 or its ligands to escape from immune surveillance.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Chemokine receptor, Cancer, Metastasis formation, Cell migration, Lymph node homing

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ISO 690LEGLER, Daniel F., Edith UETZ-VON ALLMEN, Mark A. HAUSER, 2014. CCR7 : Roles in cancer cell dissemination, migration and metastasis formation. In: The International Journal of Biochemistry & Cell Biology. 2014, 54, pp. 78-82. ISSN 1357-2725. eISSN 1878-5875. Available under: doi: 10.1016/j.biocel.2014.07.002
BibTex
@article{Legler2014Roles-29330,
  year={2014},
  doi={10.1016/j.biocel.2014.07.002},
  title={CCR7 : Roles in cancer cell dissemination, migration and metastasis formation},
  volume={54},
  issn={1357-2725},
  journal={The International Journal of Biochemistry & Cell Biology},
  pages={78--82},
  author={Legler, Daniel F. and Uetz-von Allmen, Edith and Hauser, Mark A.}
}
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