Publikation:

Demographic fluctuations and selection during host–parasite co‐evolution interactively increase genetic diversity

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Datum

2024

Autor:innen

Le Pennec, Guénolé
Retel, Cas
Kowallik, Vienna
Feulner, Philine G. D.

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Deutsche Forschungsgemeinschaft (DFG): BE4135/5, BE4135/9
Swiss National Science Foundation: 310030E‐160812
Swiss National Science Foundation: 310030E_179637

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Open Access-Veröffentlichung
Open Access Hybrid
Core Facility der Universität Konstanz

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Molecular Ecology. Wiley. 2024, 33(10), e16939. ISSN 0962-1083. eISSN 1365-294X. Verfügbar unter: doi: 10.1111/mec.16939

Zusammenfassung

Host–parasite interactions can cause strong demographic fluctuations accompanied by selective sweeps of resistance/infectivity alleles. Both demographic bottlenecks and frequent sweeps are expected to reduce the amount of segregating genetic variation and therefore might constrain adaptation during co‐evolution. Recent studies, however, suggest that the interaction of demographic and selective processes is a key component of co‐evolutionary dynamics and may rather positively affect levels of genetic diversity available for adaptation. Here, we provide direct experimental testing of this hypothesis by disentangling the effects of demography, selection and their interaction in an experimental host–parasite system. We grew 12 populations of a unicellular, asexually reproducing algae ( Chlorella variabilis ) that experienced either growth followed by constant population sizes (three populations), demographic fluctuations (three populations), selection induced by exposure to a virus (three populations), or demographic fluctuations together with virus‐induced selection (three populations). After 50 days (~50 generations), we conducted whole‐genome sequencing of each algal host population. We observed more genetic diversity in populations that jointly experienced selection and demographic fluctuations than in populations where these processes were experimentally separated. In addition, in those three populations that jointly experienced selection and demographic fluctuations, experimentally measured diversity exceeds expected values of diversity that account for the cultures' population sizes. Our results suggest that eco‐evolutionary feedbacks can positively affect genetic diversity and provide the necessary empirical measures to guide further improvements of theoretical models of adaptation during host–parasite co‐evolution.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

demography, experimental evolution, genetic diversity, host–parasite interactions, selective sweeps

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ISO 690LE PENNEC, Guénolé, Cas RETEL, Vienna KOWALLIK, Lutz BECKS, Philine G. D. FEULNER, 2024. Demographic fluctuations and selection during host–parasite co‐evolution interactively increase genetic diversity. In: Molecular Ecology. Wiley. 2024, 33(10), e16939. ISSN 0962-1083. eISSN 1365-294X. Verfügbar unter: doi: 10.1111/mec.16939
BibTex
@article{LePennec2024-05Demog-71884,
  title={Demographic fluctuations and selection during host–parasite co‐evolution interactively increase genetic diversity},
  year={2024},
  doi={10.1111/mec.16939},
  number={10},
  volume={33},
  issn={0962-1083},
  journal={Molecular Ecology},
  author={Le Pennec, Guénolé and Retel, Cas and Kowallik, Vienna and Becks, Lutz and Feulner, Philine G. D.},
  note={Article Number: e16939}
}
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Population size data, phenotypic data and data tables with nucleotide diversity are available in the Supplementary Information and are also deposited on the EAWAG research data institutional collections (https://doi.org/10.25678/0007HK). Bash scripts for the processing of sequence data and R scripts to perform other analyses and to reproduce the manuscript's figures are available on the EAWAG research data institutional collections (https://doi.org/10.25678/0007HK). All associated raw sequencing data have been deposited in the European Nucleotide Archive (Accession no. PRJEB56525).
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