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Lessons from GNE-deficient embryonic stem cells : sialic acid biosynthesis is involved in proliferation and gene expression

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2010

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Weidemann, Wenke
Klukas, Christian
Klein, Andreas
Simm, Andreas
Horstkorte, Rüdiger

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https://doi.org/10.1093/glycob/cwp153
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Glycobiology. 2010, 20(1), pp. 107-117. ISSN 0959-6658. eISSN 1460-2423. Available under: doi: 10.1093/glycob/cwp153

Zusammenfassung

Sialic acids are widely expressed as terminal carbohydrates on glycoconjugates of eukaryotic cells. They are involved in a variety of cellular functions, such as cell adhesion or signal recognition. The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), which catalyzes the first two steps of sialic acid biosynthesis in the cytosol. Inactivation of GNE causes early embryonic lethality. In this study, we analyzed wild-type and GNE-deficient embryonic stem cells from mice. We found for the first time that proliferation is directly correlated with GNE-expression and the cellular sialic acid concentration. Furthermore, we identified growth-related genes that are differentially expressed in GNE-deficient embryonic stem cells compared to wild-type embryonic stem cells.

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cell differentiation, N -acetylmannosamine , N -acetylmannosamine kinase , UDP- N -acetylglucosamine-2- epimerase

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ISO 690WEIDEMANN, Wenke, Christian KLUKAS, Andreas KLEIN, Andreas SIMM, Falk SCHREIBER, Rüdiger HORSTKORTE, 2010. Lessons from GNE-deficient embryonic stem cells : sialic acid biosynthesis is involved in proliferation and gene expression. In: Glycobiology. 2010, 20(1), pp. 107-117. ISSN 0959-6658. eISSN 1460-2423. Available under: doi: 10.1093/glycob/cwp153
BibTex
@article{Weidemann2010Lesso-40405,
  year={2010},
  doi={10.1093/glycob/cwp153},
  title={Lessons from GNE-deficient embryonic stem cells : sialic acid biosynthesis is involved in proliferation and gene expression},
  number={1},
  volume={20},
  issn={0959-6658},
  journal={Glycobiology},
  pages={107--117},
  author={Weidemann, Wenke and Klukas, Christian and Klein, Andreas and Simm, Andreas and Schreiber, Falk and Horstkorte, Rüdiger}
}
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