Publikation:

Nonglycosidic Agonists of Invariant NKT Cells for Use as Vaccine Adjuvants

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2009

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Reddy, B. Gopal
Silk, Jonathan D.
Salio, Mariolina
Balamurugan, Rengarajan
Shepherd, Dawn
Ritter, Gerd
Cerundolo, Vincenzo

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https://doi.org/10.1002/cmdc.200800354
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ChemMedChem. Wiley. 2009, 4(2), pp. 171-175. ISSN 1860-7179. eISSN 1860-7187. Available under: doi: 10.1002/cmdc.200800354

Zusammenfassung

Based on the crystal structures of human α-GalCer–CD1d and iNKT–α-GalCer–CD1d complexes, nonglycosidic analogues of α-GalCer were synthesized. They activate iNKT cells resulting in dendritic cell maturation and the priming of antigen-specific T and B cells. Therefore, they are attractive adjuvants in vaccination strategies for cancer and infectious diseases.

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ISO 690REDDY, B. Gopal, Jonathan D. SILK, Mariolina SALIO, Rengarajan BALAMURUGAN, Dawn SHEPHERD, Gerd RITTER, Vincenzo CERUNDOLO, Richard R. SCHMIDT, 2009. Nonglycosidic Agonists of Invariant NKT Cells for Use as Vaccine Adjuvants. In: ChemMedChem. Wiley. 2009, 4(2), pp. 171-175. ISSN 1860-7179. eISSN 1860-7187. Available under: doi: 10.1002/cmdc.200800354
BibTex
@article{Reddy2009-02Nongl-58157,
  year={2009},
  doi={10.1002/cmdc.200800354},
  title={Nonglycosidic Agonists of Invariant NKT Cells for Use as Vaccine Adjuvants},
  number={2},
  volume={4},
  issn={1860-7179},
  journal={ChemMedChem},
  pages={171--175},
  author={Reddy, B. Gopal and Silk, Jonathan D. and Salio, Mariolina and Balamurugan, Rengarajan and Shepherd, Dawn and Ritter, Gerd and Cerundolo, Vincenzo and Schmidt, Richard R.}
}
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