Publikation:

Interplay between stress, sleep, and BDNF in a high-risk sample of young adults

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Datum

2023

Autor:innen

Varghese, Nimmy
Buergin, David
Boonmann, Cyril
Stadler, Christina
Schmid, Marc
Eckert, Anne

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1tbvp5e4708xi0
DOI (zitierfähiger Link)
https://doi.org/10.1038/s41598-023-47726-0
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CC BY 4.0

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Open Access-Veröffentlichung
Open Access Gold

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Psychologie: Publikationen
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Published

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Scientific Reports. Springer Science and Business Media LLC. 2023, 13(1), 20524. eISSN 2045-2322. Available under: doi: 10.1038/s41598-023-47726-0

Zusammenfassung

Children in institutional care have a high risk to experience childhood adversities (CAs), with consequences for physical and mental well-being. The long-term effects of CAs on the brain, including consequences for neuronal plasticity and sleep, are poorly understood. This study examined the interplay between stress (including CAs), sleep, and brain-derived neurotrophic factor (BDNF), a prominent marker for neuronal plasticity. Participants ( N  = 131, mean age = 26.3±3.4 years, 40 females) with residential youth-care history completed questionnaires measuring CAs (Childhood Trauma Questionnaire, CTQ), psychological well-being (World Health Organization-Five Well-Being Index, WHO-5), and sleep disturbances (Pittsburgh Sleep Quality Inventory, PSQI). Hair cortisol and serum BDNF concentration were measured using enzyme-linked immunosorbent assays. The analyses were conducted by using bootstrap regression models. There was no association of stress parameters or sleep with BDNF concentration. However, we found a significant association of CAs and well-being with sleep disturbances. Last, we found an association between CAs and BDNF in sleep-healthy but not sleep-disturbed participants. Our findings indicated a role of sleep disturbance in the association between stress and BDNF. Still, further studies are warranted using vulnerable groups at-risk to understand long-term effects on mental health and sleep.

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150 Psychologie

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ISO 690VARGHESE, Nimmy, David BUERGIN, Cyril BOONMANN, Christina STADLER, Marc SCHMID, Anne ECKERT, Eva UNTERNAEHRER, 2023. Interplay between stress, sleep, and BDNF in a high-risk sample of young adults. In: Scientific Reports. Springer Science and Business Media LLC. 2023, 13(1), 20524. eISSN 2045-2322. Available under: doi: 10.1038/s41598-023-47726-0
BibTex
@article{Varghese2023-11-22Inter-69141,
  year={2023},
  doi={10.1038/s41598-023-47726-0},
  title={Interplay between stress, sleep, and BDNF in a high-risk sample of young adults},
  number={1},
  volume={13},
  journal={Scientific Reports},
  author={Varghese, Nimmy and Buergin, David and Boonmann, Cyril and Stadler, Christina and Schmid, Marc and Eckert, Anne and Unternaehrer, Eva},
  note={Article Number: 20524}
}
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