Publikation:

Long-term effects of chromium on morphological and immunological parameters of Wistar rats

Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2019

Autor:innen

Karaulov, Alexander V.
Renieri, Elisavet
Smolyagin, Alexander I.
Mikhaylova, Irina V.
Stadnikov, Alexander V.
et al.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.fct.2019.110748
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019, 133, 110748. ISSN 0278-6915. eISSN 1873-6351. Available under: doi: 10.1016/j.fct.2019.110748

Zusammenfassung

Hexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) led to a decrease in thymus mass and thymocytes' number and caused structural and functional changes in the lymph nodes and spleen, namely lymphoreticular hyperplasia and plasmocytic macrophage transformation. Programmed cell death was increased in both thymocytes and splenocytes and decreased in lymphocytes in the T-zones of spleen and lymph nodes. Moreover, Cr (VI) administration decreased myeloid cells' and neutrophils' number, while it increased lymphoid and erythroid cells' number in bone marrow. Cr (VI) immune system effects seem to be related to oxidative stress induction, as depicted by the increased levels of diene conjugates and malondialdehyde in the spleen and liver and by the decreased activity of catalase and superoxide dismutase in rats' erythrocytes. In addition, exposure to Cr (VI) decreased copper, nickel and iron concentrations in blood and liver, while Cr levels in blood, spleen and liver were increased, as expected. The observed changes in the series of immunological parameters studied contribute to the development of new approaches for the prevention of low level Cr exposure toxicity.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Chromium, Immunotoxicity, Rats, Oxidative stress, Microelements

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690KARAULOV, Alexander V., Elisavet RENIERI, Alexander I. SMOLYAGIN, Irina V. MIKHAYLOVA, Alexander V. STADNIKOV, Thomas HARTUNG, 2019. Long-term effects of chromium on morphological and immunological parameters of Wistar rats. In: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019, 133, 110748. ISSN 0278-6915. eISSN 1873-6351. Available under: doi: 10.1016/j.fct.2019.110748
BibTex
@article{Karaulov2019-11Longt-47497,
  year={2019},
  doi={10.1016/j.fct.2019.110748},
  title={Long-term effects of chromium on morphological and immunological parameters of Wistar rats},
  volume={133},
  issn={0278-6915},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  author={Karaulov, Alexander V. and Renieri, Elisavet and Smolyagin, Alexander I. and Mikhaylova, Irina V. and Stadnikov, Alexander V. and Hartung, Thomas},
  note={Article Number: 110748}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/47497">
    <dc:creator>Smolyagin, Alexander I.</dc:creator>
    <dc:creator>Mikhaylova, Irina V.</dc:creator>
    <dc:contributor>Mikhaylova, Irina V.</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:creator>Stadnikov, Alexander V.</dc:creator>
    <dcterms:abstract xml:lang="eng">Hexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) led to a decrease in thymus mass and thymocytes' number and caused structural and functional changes in the lymph nodes and spleen, namely lymphoreticular hyperplasia and plasmocytic macrophage transformation. Programmed cell death was increased in both thymocytes and splenocytes and decreased in lymphocytes in the T-zones of spleen and lymph nodes. Moreover, Cr (VI) administration decreased myeloid cells' and neutrophils' number, while it increased lymphoid and erythroid cells' number in bone marrow. Cr (VI) immune system effects seem to be related to oxidative stress induction, as depicted by the increased levels of diene conjugates and malondialdehyde in the spleen and liver and by the decreased activity of catalase and superoxide dismutase in rats' erythrocytes. In addition, exposure to Cr (VI) decreased copper, nickel and iron concentrations in blood and liver, while Cr levels in blood, spleen and liver were increased, as expected. The observed changes in the series of immunological parameters studied contribute to the development of new approaches for the prevention of low level Cr exposure toxicity.</dcterms:abstract>
    <dc:creator>Karaulov, Alexander V.</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/47497"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-11-14T14:04:26Z</dc:date>
    <dc:contributor>Renieri, Elisavet</dc:contributor>
    <dc:contributor>Hartung, Thomas</dc:contributor>
    <dc:contributor>Karaulov, Alexander V.</dc:contributor>
    <dcterms:issued>2019-11</dcterms:issued>
    <dcterms:title>Long-term effects of chromium on morphological and immunological parameters of Wistar rats</dcterms:title>
    <dc:creator>Renieri, Elisavet</dc:creator>
    <dc:contributor>Stadnikov, Alexander V.</dc:contributor>
    <dc:contributor>Smolyagin, Alexander I.</dc:contributor>
    <dc:creator>Hartung, Thomas</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-11-14T14:04:26Z</dcterms:available>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen