Publikation:

Artificial microtubules for rapid and collective transport of magnetic microcargoes

Lade...
Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2022

Autor:innen

Hanedan, Emre
Boehler, Quentin
Huang, Tian-Yun
Mathijssen, Arnold J. T. M.
Nelson, Bradley J.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Nature Machine Intelligence. Springer Nature. 2022, 4, S. 678-684. ISSN 2374-7943. eISSN 2522-5839. Verfügbar unter: doi: 10.1038/s42256-022-00510-7

Zusammenfassung

Directed transport of microcargoes is essential for living organisms as well as for applications in microrobotics, nanotechnology and biomedicine. Existing delivery technologies often suffer from low speeds, limited navigation control and dispersal by cardiovascular flows. In cell biology, these issues are largely overcome by cytoskeletal motors that carry vesicles along microtubule highways. Thus inspired, here we developed an artificial microtubule (AMT), a structured microfibre with embedded micromagnets that serve as stepping stones to guide particles rapidly through flow networks. Compared with established techniques, the microcargo travels an order of magnitude faster using the same driving frequency, and dispersal is mitigated by a strong dynamic anchoring effect. Even against strong fluid flows, the large local magnetic-field gradients enable both anchoring and guided propulsion. Finally, we show that AMTs can facilitate the self-assembly of microparticles into active-matter clusters, which then enhance their walking speed by bridging over stepping stones collectively. Hence, we demonstrate a unique strategy for robust delivery inside microvascular networks and for minimally invasive interventions, with non-equilibrium effects that could be equally relevant for enhancing biological transport processes.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
530 Physik

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690GU, Hongri, Emre HANEDAN, Quentin BOEHLER, Tian-Yun HUANG, Arnold J. T. M. MATHIJSSEN, Bradley J. NELSON, 2022. Artificial microtubules for rapid and collective transport of magnetic microcargoes. In: Nature Machine Intelligence. Springer Nature. 2022, 4, S. 678-684. ISSN 2374-7943. eISSN 2522-5839. Verfügbar unter: doi: 10.1038/s42256-022-00510-7
BibTex
@article{Gu2022Artif-58226,
  year={2022},
  doi={10.1038/s42256-022-00510-7},
  title={Artificial microtubules for rapid and collective transport of magnetic microcargoes},
  volume={4},
  issn={2374-7943},
  journal={Nature Machine Intelligence},
  pages={678--684},
  author={Gu, Hongri and Hanedan, Emre and Boehler, Quentin and Huang, Tian-Yun and Mathijssen, Arnold J. T. M. and Nelson, Bradley J.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/58226">
    <dcterms:issued>2022</dcterms:issued>
    <dc:contributor>Huang, Tian-Yun</dc:contributor>
    <dc:contributor>Boehler, Quentin</dc:contributor>
    <dc:contributor>Mathijssen, Arnold J. T. M.</dc:contributor>
    <dc:creator>Gu, Hongri</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-08-03T13:01:40Z</dc:date>
    <dc:contributor>Gu, Hongri</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:language>eng</dc:language>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-08-03T13:01:40Z</dcterms:available>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/41"/>
    <dcterms:abstract xml:lang="eng">Directed transport of microcargoes is essential for living organisms as well as for applications in microrobotics, nanotechnology and biomedicine. Existing delivery technologies often suffer from low speeds, limited navigation control and dispersal by cardiovascular flows. In cell biology, these issues are largely overcome by cytoskeletal motors that carry vesicles along microtubule highways. Thus inspired, here we developed an artificial microtubule (AMT), a structured microfibre with embedded micromagnets that serve as stepping stones to guide particles rapidly through flow networks. Compared with established techniques, the microcargo travels an order of magnitude faster using the same driving frequency, and dispersal is mitigated by a strong dynamic anchoring effect. Even against strong fluid flows, the large local magnetic-field gradients enable both anchoring and guided propulsion. Finally, we show that AMTs can facilitate the self-assembly of microparticles into active-matter clusters, which then enhance their walking speed by bridging over stepping stones collectively. Hence, we demonstrate a unique strategy for robust delivery inside microvascular networks and for minimally invasive interventions, with non-equilibrium effects that could be equally relevant for enhancing biological transport processes.</dcterms:abstract>
    <dc:contributor>Nelson, Bradley J.</dc:contributor>
    <dc:creator>Nelson, Bradley J.</dc:creator>
    <dc:creator>Huang, Tian-Yun</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/41"/>
    <dc:creator>Mathijssen, Arnold J. T. M.</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Hanedan, Emre</dc:creator>
    <dc:creator>Boehler, Quentin</dc:creator>
    <dc:contributor>Hanedan, Emre</dc:contributor>
    <dcterms:title>Artificial microtubules for rapid and collective transport of magnetic microcargoes</dcterms:title>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/58226"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Ja
Diese Publikation teilen