The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

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Oberlin_0-367196.pdf
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1996
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Oberlin, Estelle
Amara, Ali
Bachelerie, Franc˛oise
Bessia, Christine
Virelizier, Jean-Louis
Arenzana-Seisdedos, Fernando
Schwartz, Olivier
Heard, Jean-Michel
Moser, Bernhard
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Nature. 1996, 382(6594), pp. 833-835. ISSN 0028-0836. eISSN 1476-4687. Available under: doi: 10.1038/382833a0
Zusammenfassung

A putative chemokine receptor that we previously cloned and termed LESTR has recently been shown to function as a co-receptor (termed fusin) for lymphocyte-tropic HIV-1 strains. Cells expressing CD4 became permissive to infection with T-cell-line-adapted HIV-1 strains of the syncytium-inducing phenotype after transfection with LESTR/fusin complementary DNA. We report here the indentification of a human chemokine of the CXC type, stromal cell-derived factor 1 (SDF-1), as the natural ligand for LESTR/fusin, and we propose the term CXCR-4 for this receptor, in keeping with the new chemokine-receptor nomenclature. SDF-1 activates Chinese hamster ovary (CHO) cells transfected with CXCR-4 cDNA as well as blood leukocytes and lymphocytes. In cell lines expressing CXCR-4 and CD4, and in blood lymphocytes, SDF-1 is a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains, whereas the CC chemokines RANTES, MIP-1 alpha and MIP-1 beta, which were shown previously to prevent infection with primary, monocyte-tropic viruses, are inactive. In combination with CC chemokines, which block the infection with monocyte/macrophage-tropic viruses, SDF-1 could help to decrease virus load and prevent the emergence of the syncytium-inducing viruses which are characteristic of the late stages of AIDS.

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570 Biowissenschaften, Biologie
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ISO 690OBERLIN, Estelle, Ali AMARA, Franc˛oise BACHELERIE, Christine BESSIA, Jean-Louis VIRELIZIER, Fernando ARENZANA-SEISDEDOS, Olivier SCHWARTZ, Jean-Michel HEARD, Daniel F. LEGLER, Bernhard MOSER, 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. In: Nature. 1996, 382(6594), pp. 833-835. ISSN 0028-0836. eISSN 1476-4687. Available under: doi: 10.1038/382833a0
BibTex
@article{Oberlin1996-08-29chemo-37569,
  year={1996},
  doi={10.1038/382833a0},
  title={The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1},
  number={6594},
  volume={382},
  issn={0028-0836},
  journal={Nature},
  pages={833--835},
  author={Oberlin, Estelle and Amara, Ali and Bachelerie, Franc˛oise and Bessia, Christine and Virelizier, Jean-Louis and Arenzana-Seisdedos, Fernando and Schwartz, Olivier and Heard, Jean-Michel and Legler, Daniel F. and Moser, Bernhard}
}
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    <dcterms:abstract xml:lang="eng">A putative chemokine receptor that we previously cloned and termed LESTR has recently been shown to function as a co-receptor (termed fusin) for lymphocyte-tropic HIV-1 strains. Cells expressing CD4 became permissive to infection with T-cell-line-adapted HIV-1 strains of the syncytium-inducing phenotype after transfection with LESTR/fusin complementary DNA. We report here the indentification of a human chemokine of the CXC type, stromal cell-derived factor 1 (SDF-1), as the natural ligand for LESTR/fusin, and we propose the term CXCR-4 for this receptor, in keeping with the new chemokine-receptor nomenclature. SDF-1 activates Chinese hamster ovary (CHO) cells transfected with CXCR-4 cDNA as well as blood leukocytes and lymphocytes. In cell lines expressing CXCR-4 and CD4, and in blood lymphocytes, SDF-1 is a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains, whereas the CC chemokines RANTES, MIP-1 alpha and MIP-1 beta, which were shown previously to prevent infection with primary, monocyte-tropic viruses, are inactive. In combination with CC chemokines, which block the infection with monocyte/macrophage-tropic viruses, SDF-1 could help to decrease virus load and prevent the emergence of the syncytium-inducing viruses which are characteristic of the late stages of AIDS.</dcterms:abstract>
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