Computing optimal drug dosing with OptiDose : implementation in NONMEM

Kurzanzeige
dc.contributor.authorBachmann, Freya
dc.contributor.authorKoch, Gilbert
dc.contributor.authorBauer, Robert J.
dc.contributor.authorSteffens, Britta
dc.contributor.authorSzinnai, Gabor
dc.contributor.authorPfister, Marc
dc.contributor.authorSchropp, Johannes
dc.date.accessioned2024-10-09T11:09:58Z
dc.date.available2024-10-09T11:09:58Z
dc.date.issued2023-06
dc.description.abstractDetermining a drug dosing recommendation with a PKPD model can be a laborious and complex task. Recently, an optimal dosing algorithm (OptiDose) was developed to compute the optimal doses for any pharmacometrics/PKPD model for a given dosing scenario. In the present work, we reformulate the underlying optimal control problem and elaborate how to solve it with standard commands in the software NONMEM. To demonstrate the potential of the OptiDose implementation in NONMEM, four relevant but substantially different optimal dosing tasks are solved. In addition, the impact of different dosing scenarios as well as the choice of the therapeutic goal on the computed optimal doses are discussed.
dc.description.versionpublisheddeu
dc.identifier.doi10.1007/s10928-022-09840-w
dc.identifier.ppn1968843132
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/70945
dc.language.isoeng
dc.rightsterms-of-use
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/
dc.subjectOptimal control
dc.subjectOptimal dosing
dc.subjectDose optimization
dc.subjectTherapeutic goal
dc.subjectPharmacometrics
dc.subject.ddc510
dc.titleComputing optimal drug dosing with OptiDose : implementation in NONMEMeng
dc.typeJOURNAL_ARTICLE
dspace.entity.typePublication
kops.citation.bibtex
@article{Bachmann2023-06Compu-70945,
  title={Computing optimal drug dosing with OptiDose : implementation in NONMEM},
  year={2023},
  doi={10.1007/s10928-022-09840-w},
  number={3},
  volume={50},
  issn={1567-567X},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  pages={173--188},
  author={Bachmann, Freya and Koch, Gilbert and Bauer, Robert J. and Steffens, Britta and Szinnai, Gabor and Pfister, Marc and Schropp, Johannes}
}
kops.citation.iso690BACHMANN, Freya, Gilbert KOCH, Robert J. BAUER, Britta STEFFENS, Gabor SZINNAI, Marc PFISTER, Johannes SCHROPP, 2023. Computing optimal drug dosing with OptiDose : implementation in NONMEM. In: Journal of Pharmacokinetics and Pharmacodynamics. Springer. 2023, 50(3), S. 173-188. ISSN 1567-567X. eISSN 1573-8744. Verfügbar unter: doi: 10.1007/s10928-022-09840-wdeu
kops.citation.iso690BACHMANN, Freya, Gilbert KOCH, Robert J. BAUER, Britta STEFFENS, Gabor SZINNAI, Marc PFISTER, Johannes SCHROPP, 2023. Computing optimal drug dosing with OptiDose : implementation in NONMEM. In: Journal of Pharmacokinetics and Pharmacodynamics. Springer. 2023, 50(3), pp. 173-188. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-022-09840-weng
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