Publikation:

Structure and function of the porin channel

Lade...
Vorschaubild

Dateien

Welte_208907.pdf
Welte_208907.pdfGröße: 8.95 MBDownloads: 961

Datum

1995

Autor:innen

Nestel, Uwe
Wacker, Thomas

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

DOI (zitierfähiger Link)
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Kidney International. 1995, 48(4), pp. 930-940. ISSN 0085-2538. eISSN 1523-1755. Available under: doi: 10.1038/ki.1995.374

Zusammenfassung

The outer membrane bilayer of gram-negative bacteria, which encapsulates completely the plasma membrane, seems to act as a protection system against noxious macromolecules like proteases and bile-salt micelles [1]. The external monolayer is composed of lipopolysaccharides with a variable carbohydrate composition. Long oligosaccharide chains protect the cells against recognition by the complement system [2, 3] and hydrophobic substances [4]. The other monolayer facing the periplasmic space is mainly composed of phospholipid.

This protection system should nevertheless allow free access of small biomolecules like mono- and disaccharides, nucleosides, and amino acids to the cytoplasmic membrane. The proteins allowing for rapid diffusion of these molecules across the outer membrane are called porins [5]. The "general diffusion porins" form aqueous channels with an exclusion limit of typically 600 Da and extremes of 5000 Da. Due to their high copy number they form the major integral protein component of the outer membrane and turn it into a molecular sieve. A single cell of E. coli has been estimated to possess approximately 105 OmpF porin molecules [6].

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690WELTE, Wolfram, Uwe NESTEL, Thomas WACKER, Kay DIEDERICHS, 1995. Structure and function of the porin channel. In: Kidney International. 1995, 48(4), pp. 930-940. ISSN 0085-2538. eISSN 1523-1755. Available under: doi: 10.1038/ki.1995.374
BibTex
@article{Welte1995Struc-20890,
  year={1995},
  doi={10.1038/ki.1995.374},
  title={Structure and function of the porin channel},
  number={4},
  volume={48},
  issn={0085-2538},
  journal={Kidney International},
  pages={930--940},
  author={Welte, Wolfram and Nestel, Uwe and Wacker, Thomas and Diederichs, Kay}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/20890">
    <dc:creator>Nestel, Uwe</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-11-20T07:58:33Z</dc:date>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Welte, Wolfram</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:title>Structure and function of the porin channel</dcterms:title>
    <dcterms:issued>1995</dcterms:issued>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/20890/2/Welte_208907.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:bibliographicCitation>Kidney International ; 48 (1995), 4. - S. 930-940</dcterms:bibliographicCitation>
    <dc:language>eng</dc:language>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/20890"/>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-11-20T07:58:33Z</dcterms:available>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Nestel, Uwe</dc:contributor>
    <dcterms:abstract xml:lang="eng">The outer membrane bilayer of gram-negative bacteria, which encapsulates completely the plasma membrane, seems to act as a protection system against noxious macromolecules like proteases and bile-salt micelles [1]. The external monolayer is composed of lipopolysaccharides with a variable carbohydrate composition. Long oligosaccharide chains protect the cells against recognition by the complement system [2, 3] and hydrophobic substances [4]. The other monolayer facing the periplasmic space is mainly composed of phospholipid.&lt;br /&gt;&lt;br /&gt;This protection system should nevertheless allow free access of small biomolecules like mono- and disaccharides, nucleosides, and amino acids to the cytoplasmic membrane. The proteins allowing for rapid diffusion of these molecules across the outer membrane are called porins [5]. The "general diffusion porins" form aqueous channels with an exclusion limit of typically 600 Da and extremes of 5000 Da. Due to their high copy number they form the major integral protein component of the outer membrane and turn it into a molecular sieve. A single cell of E. coli has been estimated to possess approximately 105 OmpF porin molecules [6].</dcterms:abstract>
    <dc:contributor>Diederichs, Kay</dc:contributor>
    <dc:creator>Diederichs, Kay</dc:creator>
    <dc:contributor>Welte, Wolfram</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/20890/2/Welte_208907.pdf"/>
    <dc:creator>Wacker, Thomas</dc:creator>
    <dc:contributor>Wacker, Thomas</dc:contributor>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen