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Peptide antigen production by the proteasome : complexity provides efficiency

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1996

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Soza, Andrea
Kuckelkorn, Ulrike
Kloetzel, Peter M.

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Core Facility der Universität Konstanz

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Published

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Immunology Today. 1996, 17(9), pp. 429-435. ISSN 0167-5699. eISSN 1355-8242. Available under: doi: 10.1016/0167-5699(96)10051-7

Zusammenfassung

Proteasomes have recently been shown to be central to the production of antigenic peptides that can bind to major histocompatibility complex class I molecules. Here, Marcus Groettrup and colleagues discuss the structural architecture of the proteasome and its proteolytic mechanisms with respect to the generation of antigenic peptides. They suggest that exchanges of proteolytic proteasome subunits and proteasome activators cooperate to optimize the production of antigens for cytotoxic T cells.

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570 Biowissenschaften, Biologie

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ISO 690GRÖTTRUP, Marcus, Andrea SOZA, Ulrike KUCKELKORN, Peter M. KLOETZEL, 1996. Peptide antigen production by the proteasome : complexity provides efficiency. In: Immunology Today. 1996, 17(9), pp. 429-435. ISSN 0167-5699. eISSN 1355-8242. Available under: doi: 10.1016/0167-5699(96)10051-7
BibTex
@article{Grottrup1996Pepti-22250,
  year={1996},
  doi={10.1016/0167-5699(96)10051-7},
  title={Peptide antigen production by the proteasome : complexity provides efficiency},
  number={9},
  volume={17},
  issn={0167-5699},
  journal={Immunology Today},
  pages={429--435},
  author={Gröttrup, Marcus and Soza, Andrea and Kuckelkorn, Ulrike and Kloetzel, Peter M.}
}
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