Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa

Kurzanzeige
dc.contributor.authorSzamosvari, David
dc.contributor.authorReichle, Valentin F.
dc.contributor.authorJureschi, Monica
dc.contributor.authorBöttcher, Thomas
dc.date.accessioned2017-02-17T14:29:15Z
dc.date.available2017-02-17T14:29:15Z
dc.date.issued2016eng
dc.description.abstractWe explore the chemical space of Pseudomonas quinolone signal analogs as privileged structures and report the discovery of a thioquinolone as a potent inhibitor of the important virulence factor elastase of the human pathogen Pseudomonas aeruginosa. We provide evidence that the derivative binds to the active site zinc of elastase and additionally acts as a fluorescent zinc sensor.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1039/c6cc06295deng
dc.identifier.pmid27722551eng
dc.identifier.ppn485923076
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/37585
dc.language.isoengeng
dc.rightsAttribution 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subject.ddc540eng
dc.titleSynthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosaeng
dc.typeJOURNAL_ARTICLEeng
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kops.citation.bibtex
@article{Szamosvari2016Synth-37585,
  year={2016},
  doi={10.1039/c6cc06295d},
  title={Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa},
  number={92},
  volume={52},
  issn={0009-241X},
  journal={Chemical Communications : ChemComm},
  pages={13440--13443},
  author={Szamosvari, David and Reichle, Valentin F. and Jureschi, Monica and Böttcher, Thomas}
}
kops.citation.iso690SZAMOSVARI, David, Valentin F. REICHLE, Monica JURESCHI, Thomas BÖTTCHER, 2016. Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa. In: Chemical Communications : ChemComm. 2016, 52(92), pp. 13440-13443. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/c6cc06295ddeu
kops.citation.iso690SZAMOSVARI, David, Valentin F. REICHLE, Monica JURESCHI, Thomas BÖTTCHER, 2016. Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa. In: Chemical Communications : ChemComm. 2016, 52(92), pp. 13440-13443. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/c6cc06295deng
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