Publikation: Advances in 3D neuronal microphysiological systems : towards a functional nervous system on a chip
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Microphysiological systems (MPS) designed to study the complexities of the peripheral and central nervous systems have made marked improvements over the years and have allowed researchers to assess in two and three dimensions the functional interconnectivity of neuronal tissues. The recent generation of brain organoids has further propelled the field into the nascent recapitulation of structural, functional, and effective connectivities which are found within the native human nervous system. Herein, we will review advances in culture methodologies, focused especially on those of human tissues, which seek to bridge the gap from 2D cultures to hierarchical and defined 3D MPS with the end goal of developing a robust nervous system-on-a-chip platform. These advances have far-reaching implications within basic science, pharmaceutical development, and translational medicine disciplines.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
ANDERSON, Wesley A., Alexander BOSAK, Helena T. HOGBERG, Thomas HARTUNG, Michael J. MOORE, 2021. Advances in 3D neuronal microphysiological systems : towards a functional nervous system on a chip. In: In Vitro Cellular & Developmental Biology - Animal. Springer. 2021, 57(2), pp. 191-206. ISSN 1071-2690. eISSN 1543-706X. Available under: doi: 10.1007/s11626-020-00532-8BibTex
@article{Anderson2021-02Advan-52690, year={2021}, doi={10.1007/s11626-020-00532-8}, title={Advances in 3D neuronal microphysiological systems : towards a functional nervous system on a chip}, number={2}, volume={57}, issn={1071-2690}, journal={In Vitro Cellular & Developmental Biology - Animal}, pages={191--206}, author={Anderson, Wesley A. and Bosak, Alexander and Hogberg, Helena T. and Hartung, Thomas and Moore, Michael J.} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52690"> <dc:contributor>Anderson, Wesley A.</dc:contributor> <dcterms:issued>2021-02</dcterms:issued> <dc:creator>Hartung, Thomas</dc:creator> <dc:contributor>Hartung, Thomas</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dcterms:abstract xml:lang="eng">Microphysiological systems (MPS) designed to study the complexities of the peripheral and central nervous systems have made marked improvements over the years and have allowed researchers to assess in two and three dimensions the functional interconnectivity of neuronal tissues. The recent generation of brain organoids has further propelled the field into the nascent recapitulation of structural, functional, and effective connectivities which are found within the native human nervous system. Herein, we will review advances in culture methodologies, focused especially on those of human tissues, which seek to bridge the gap from 2D cultures to hierarchical and defined 3D MPS with the end goal of developing a robust nervous system-on-a-chip platform. These advances have far-reaching implications within basic science, pharmaceutical development, and translational medicine disciplines.</dcterms:abstract> <dc:creator>Moore, Michael J.</dc:creator> <dc:creator>Anderson, Wesley A.</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dcterms:title>Advances in 3D neuronal microphysiological systems : towards a functional nervous system on a chip</dcterms:title> <dc:contributor>Hogberg, Helena T.</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/52690"/> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:rights>Attribution 4.0 International</dc:rights> <dc:creator>Bosak, Alexander</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:contributor>Bosak, Alexander</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-02-03T08:14:34Z</dcterms:available> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/52690/1/Anderson_2-18948l6uibdsm2.pdf"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/52690/1/Anderson_2-18948l6uibdsm2.pdf"/> <dc:creator>Hogberg, Helena T.</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-02-03T08:14:34Z</dc:date> <dc:contributor>Moore, Michael J.</dc:contributor> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>