Publikation: Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
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Datum
2002
Autor:innen
Fujita, Yasuyuki
Krause, Gerd
Zechner, Dietmar
Leddy, Hugo E Molina
Behrens, Jürgen
Sommer, Thomas
Birchmeier, Walter
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Nature cell biology. 2002, 4(3), pp. 222-231. ISSN 1465-7392. eISSN 1476-4679. Available under: doi: 10.1038/ncb758
Zusammenfassung
In epithelial cells, tyrosine kinases induce the tyrosine phosphorylation and ubiquitination of the E-cadherin complex, which induces endocytosis of E-cadherin. With a modified yeast 2-hybrid system, we isolated Hakai, an E-cadherin binding protein, which we have identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and proline-rich domains, and interacts with E-cadherin in a tyrosine phosphorylation-dependent manner, inducing ubiquitination of the E-cadherin complex. Expression of Hakai in epithelial cells disrupts cell--cell contacts and enhances endocytosis of E-cadherin and cell motility. Through dynamic recycling of E-cadherin, Hakai can thus modulate cell adhesion, and could participate in the regulation of epithelial--mesenchymal transitions in development or metastasis.
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570 Biowissenschaften, Biologie
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FUJITA, Yasuyuki, Gerd KRAUSE, Martin SCHEFFNER, Dietmar ZECHNER, Hugo E Molina LEDDY, Jürgen BEHRENS, Thomas SOMMER, Walter BIRCHMEIER, 2002. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. In: Nature cell biology. 2002, 4(3), pp. 222-231. ISSN 1465-7392. eISSN 1476-4679. Available under: doi: 10.1038/ncb758BibTex
@article{Fujita2002-03Hakai-42453,
year={2002},
doi={10.1038/ncb758},
title={Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex},
number={3},
volume={4},
issn={1465-7392},
journal={Nature cell biology},
pages={222--231},
author={Fujita, Yasuyuki and Krause, Gerd and Scheffner, Martin and Zechner, Dietmar and Leddy, Hugo E Molina and Behrens, Jürgen and Sommer, Thomas and Birchmeier, Walter}
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