Publikation:

Ageing and PARP

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2005

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Diefenbach, Jörg
Brabeck, Christine

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https://doi.org/10.1016/j.phrs.2005.02.008
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Published

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Pharmacological Research. Elsevier. 2005, 52(1), pp. 93-99. ISSN 1043-6618. eISSN 1096-1186. Available under: doi: 10.1016/j.phrs.2005.02.008

Zusammenfassung

Poly(ADP-ribosyl)ation, which is the posttranslational modification of proteins with poly(ADP-ribose), is catalysed by poly(ADP-ribose) polymerases. DNA-strand break induced catalytic activation of two PARP isoforms, namely PARP-1 and -2, are in involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA-damage induced poly(ADP-ribosyl)ation and mammalian longevity. This notion was reinforced by recently published evidence for interactions between PARP-1 and the Werner syndrome protein, deficiency of which causes premature ageing in humans. Recent research on PARPs and poly(ADP-ribose) provides several candidate mechanisms through which poly(ADP-ribosyl)ation might contribute to keeping the ageing process at slow pace.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

DNA repair, Genomic stability, PARP, Poly(ADP-ribosyl)ation, Telomere

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ISO 690BÜRKLE, Alexander, Jörg DIEFENBACH, Christine BRABECK, Sascha BENEKE, 2005. Ageing and PARP. In: Pharmacological Research. Elsevier. 2005, 52(1), pp. 93-99. ISSN 1043-6618. eISSN 1096-1186. Available under: doi: 10.1016/j.phrs.2005.02.008
BibTex
@article{Burkle2005-07Agein-52110,
  year={2005},
  doi={10.1016/j.phrs.2005.02.008},
  title={Ageing and PARP},
  number={1},
  volume={52},
  issn={1043-6618},
  journal={Pharmacological Research},
  pages={93--99},
  author={Bürkle, Alexander and Diefenbach, Jörg and Brabeck, Christine and Beneke, Sascha}
}
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