Ageing and PARP

Kurzanzeige
dc.contributor.authorBürkle, Alexander
dc.contributor.authorDiefenbach, Jörg
dc.contributor.authorBrabeck, Christine
dc.contributor.authorBeneke, Sascha
dc.date.accessioned2020-12-15T08:21:49Z
dc.date.available2020-12-15T08:21:49Z
dc.date.issued2005-07eng
dc.description.abstractPoly(ADP-ribosyl)ation, which is the posttranslational modification of proteins with poly(ADP-ribose), is catalysed by poly(ADP-ribose) polymerases. DNA-strand break induced catalytic activation of two PARP isoforms, namely PARP-1 and -2, are in involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA-damage induced poly(ADP-ribosyl)ation and mammalian longevity. This notion was reinforced by recently published evidence for interactions between PARP-1 and the Werner syndrome protein, deficiency of which causes premature ageing in humans. Recent research on PARPs and poly(ADP-ribose) provides several candidate mechanisms through which poly(ADP-ribosyl)ation might contribute to keeping the ageing process at slow pace.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1016/j.phrs.2005.02.008eng
dc.identifier.pmid15911337eng
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/52110
dc.language.isoengeng
dc.rightsterms-of-use
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/
dc.subjectDNA repair, Genomic stability, PARP, Poly(ADP-ribosyl)ation, Telomereeng
dc.subject.ddc570eng
dc.titleAgeing and PARPeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
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  doi={10.1016/j.phrs.2005.02.008},
  title={Ageing and PARP},
  number={1},
  volume={52},
  issn={1043-6618},
  journal={Pharmacological Research},
  pages={93--99},
  author={Bürkle, Alexander and Diefenbach, Jörg and Brabeck, Christine and Beneke, Sascha}
}
kops.citation.iso690BÜRKLE, Alexander, Jörg DIEFENBACH, Christine BRABECK, Sascha BENEKE, 2005. Ageing and PARP. In: Pharmacological Research. Elsevier. 2005, 52(1), pp. 93-99. ISSN 1043-6618. eISSN 1096-1186. Available under: doi: 10.1016/j.phrs.2005.02.008deu
kops.citation.iso690BÜRKLE, Alexander, Jörg DIEFENBACH, Christine BRABECK, Sascha BENEKE, 2005. Ageing and PARP. In: Pharmacological Research. Elsevier. 2005, 52(1), pp. 93-99. ISSN 1043-6618. eISSN 1096-1186. Available under: doi: 10.1016/j.phrs.2005.02.008eng
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kops.sourcefieldPharmacological Research. Elsevier. 2005, <b>52</b>(1), pp. 93-99. ISSN 1043-6618. eISSN 1096-1186. Available under: doi: 10.1016/j.phrs.2005.02.008deu
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