Publikation:

Sex differences in the cortisol response to awakening in recent onset psychosis

Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2008

Autor:innen

Boekestyn, Ludmila
Béchard-Evans, Laura
Abadi, Sherezad
Vracotas, Nadia
Joober, Ridha
Malla, Ashok K.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.psyneuen.2008.04.006
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung

Sammlungen

Psychologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Psychoneuroendocrinology. 2008, 33(8), pp. 1151-1154. ISSN 0306-4530. eISSN 1873-3360. Available under: doi: 10.1016/j.psyneuen.2008.04.006

Zusammenfassung

A dysregulation of the hypothalamus–pituitary–adrenal (HPA) axis has been suggested as a factor in the etiology and exacerbation of psychosis, but has not been reported consistently. Sex differences are apparent in many aspects of psychotic disorders and may explain some of the equivocation associated with the regulation of the HPA axis in the illness.
The present study compared the cortisol response to awakening (CRA) in 27 patients (16 men and 11 women) with recent onset of psychosis (within the past 2 years) and 40 age and gender matched controls. Within the patient group, we also assessed the relationship between the CRA and positive and negative symptoms of psychosis, anxiety and depression.
he CRA in patients was not significantly different from controls. However, within the patient group, we observed a significant sex difference, with a blunted cortisol response to awakening in men but not in women (F = 7.26; p < 0.002). This difference could not be explained by differences between male and female patients in awakening time, medication, or diagnosis of schizophrenia vs. affective psychosis. Cortisol levels were not related to symptom measures.
Our findings demonstrate a dysregulation of the HPA axis in male patients with recent onset of psychosis. This sex specificity might be related to and explain in part the unfavorable course of the illness observed in men.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
150 Psychologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Verknüpfte Datensätze

Zitieren

ISO 690PRUESSNER, Marita, Ludmila BOEKESTYN, Laura BÉCHARD-EVANS, Sherezad ABADI, Nadia VRACOTAS, Ridha JOOBER, Jens C. PRUESSNER, Ashok K. MALLA, 2008. Sex differences in the cortisol response to awakening in recent onset psychosis. In: Psychoneuroendocrinology. 2008, 33(8), pp. 1151-1154. ISSN 0306-4530. eISSN 1873-3360. Available under: doi: 10.1016/j.psyneuen.2008.04.006
BibTex
@article{Pruessner2008-09diffe-41416,
  year={2008},
  doi={10.1016/j.psyneuen.2008.04.006},
  title={Sex differences in the cortisol response to awakening in recent onset psychosis},
  number={8},
  volume={33},
  issn={0306-4530},
  journal={Psychoneuroendocrinology},
  pages={1151--1154},
  author={Pruessner, Marita and Boekestyn, Ludmila and Béchard-Evans, Laura and Abadi, Sherezad and Vracotas, Nadia and Joober, Ridha and Pruessner, Jens C. and Malla, Ashok K.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/41416">
    <dc:contributor>Pruessner, Marita</dc:contributor>
    <dc:contributor>Pruessner, Jens C.</dc:contributor>
    <dc:contributor>Béchard-Evans, Laura</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-02-19T08:03:27Z</dc:date>
    <dc:contributor>Joober, Ridha</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-02-19T08:03:27Z</dcterms:available>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dcterms:issued>2008-09</dcterms:issued>
    <dc:creator>Abadi, Sherezad</dc:creator>
    <dc:creator>Béchard-Evans, Laura</dc:creator>
    <dc:creator>Pruessner, Marita</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Pruessner, Jens C.</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/41416"/>
    <dc:creator>Vracotas, Nadia</dc:creator>
    <dc:contributor>Vracotas, Nadia</dc:contributor>
    <dc:creator>Boekestyn, Ludmila</dc:creator>
    <dc:contributor>Abadi, Sherezad</dc:contributor>
    <dcterms:title>Sex differences in the cortisol response to awakening in recent onset psychosis</dcterms:title>
    <dc:contributor>Malla, Ashok K.</dc:contributor>
    <dc:creator>Malla, Ashok K.</dc:creator>
    <dc:contributor>Boekestyn, Ludmila</dc:contributor>
    <dc:creator>Joober, Ridha</dc:creator>
    <dc:language>eng</dc:language>
    <dcterms:abstract xml:lang="eng">A dysregulation of the hypothalamus–pituitary–adrenal (HPA) axis has been suggested as a factor in the etiology and exacerbation of psychosis, but has not been reported consistently. Sex differences are apparent in many aspects of psychotic disorders and may explain some of the equivocation associated with the regulation of the HPA axis in the illness.&lt;br /&gt;The present study compared the cortisol response to awakening (CRA) in 27 patients (16 men and 11 women) with recent onset of psychosis (within the past 2 years) and 40 age and gender matched controls. Within the patient group, we also assessed the relationship between the CRA and positive and negative symptoms of psychosis, anxiety and depression.&lt;br /&gt;he CRA in patients was not significantly different from controls. However, within the patient group, we observed a significant sex difference, with a blunted cortisol response to awakening in men but not in women (F = 7.26; p &lt; 0.002). This difference could not be explained by differences between male and female patients in awakening time, medication, or diagnosis of schizophrenia vs. affective psychosis. Cortisol levels were not related to symptom measures.&lt;br /&gt;Our findings demonstrate a dysregulation of the HPA axis in male patients with recent onset of psychosis. This sex specificity might be related to and explain in part the unfavorable course of the illness observed in men.</dcterms:abstract>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen