Pogostol biosynthesis by the endophytic fungus Geniculosporium

Kurzanzeige
dc.contributor.authorBarra, Lena
dc.contributor.authorSchulz, Barbara
dc.contributor.authorDickschat, Jeroen S.
dc.date.accessioned2022-05-10T09:55:49Z
dc.date.available2022-05-10T09:55:49Z
dc.date.issued2014-11-03eng
dc.description.abstractSix 13C-labelled isotopomers of mevalonolactone were synthesised and used in feeding experiments with the endophytic fungus Geniculosporium. The high incorporation rates of 13C-label into a sesquiterpene that was found in headspace extracts of the fungus enabled unambiguous identification of this volatile as pogostol without the need for compound purification, simply by collecting the volatile fraction with a closed-loop stripping apparatus followed by direct 13C NMR analysis (CLSA-NMR). The feeding experiments also gave insights into the biosynthesis of pogostol, including stereochemical aspects of the terpene cyclisation reaction. The possible biological function of pogostol is discussed.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1002/cbic.201402298eng
dc.identifier.pmid25186118eng
dc.identifier.ppn1841631698
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/57484
dc.language.isoengeng
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dc.subject.ddc540eng
dc.titlePogostol biosynthesis by the endophytic fungus Geniculosporiumeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Barra2014-11-03Pogos-57484,
  year={2014},
  doi={10.1002/cbic.201402298},
  title={Pogostol biosynthesis by the endophytic fungus Geniculosporium},
  number={16},
  volume={15},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={2379--2383},
  author={Barra, Lena and Schulz, Barbara and Dickschat, Jeroen S.}
}
kops.citation.iso690BARRA, Lena, Barbara SCHULZ, Jeroen S. DICKSCHAT, 2014. Pogostol biosynthesis by the endophytic fungus Geniculosporium. In: ChemBioChem. Wiley. 2014, 15(16), pp. 2379-2383. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201402298deu
kops.citation.iso690BARRA, Lena, Barbara SCHULZ, Jeroen S. DICKSCHAT, 2014. Pogostol biosynthesis by the endophytic fungus Geniculosporium. In: ChemBioChem. Wiley. 2014, 15(16), pp. 2379-2383. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201402298eng
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    <dcterms:abstract xml:lang="eng">Six &lt;sup&gt;13&lt;/sup&gt;C-labelled isotopomers of mevalonolactone were synthesised and used in feeding experiments with the endophytic fungus Geniculosporium. The high incorporation rates of &lt;sup&gt;13&lt;/sup&gt;C-label into a sesquiterpene that was found in headspace extracts of the fungus enabled unambiguous identification of this volatile as pogostol without the need for compound purification, simply by collecting the volatile fraction with a closed-loop stripping apparatus followed by direct &lt;sup&gt;13&lt;/sup&gt;C NMR analysis (CLSA-NMR). The feeding experiments also gave insights into the biosynthesis of pogostol, including stereochemical aspects of the terpene cyclisation reaction. The possible biological function of pogostol is discussed.</dcterms:abstract>
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