Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5

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dc.contributor.authorSunder-Plassmann, Nilsdeu
dc.contributor.authorSarli, Vasilikideu
dc.contributor.authorGartner, Michaeldeu
dc.contributor.authorUtz, Mathiasdeu
dc.contributor.authorSeiler, Jeanettedeu
dc.contributor.authorHuemmer, Stefandeu
dc.contributor.authorMayer, Thomas U.
dc.contributor.authorSurrey, Thomasdeu
dc.contributor.authorGiannis, Athanassiosdeu
dc.date.accessioned2011-12-14T10:22:08Zdeu
dc.date.available2011-12-14T10:22:08Zdeu
dc.date.issued2005-11-15
dc.description.abstractThe mitotic kinesin Eg5 (or KSP) is a crucial player in the development and function of the mitotic spindle. Inhibition of this protein leads to cell cycle arrest and apoptosis without interfering with other microtubule-dependent processes. Therefore, it is a potential target in cancer therapy. Here, we report the synthesis and biological evaluation of a small library of molecules based on the structure of the known Eg5 inhibitor HR22C16. One of these derivatives (compound trans-24) proved to be a potent and specific Eg5 inhibitor.eng
dc.description.versionpublished
dc.identifier.citationPubl. in: Bioorganic & Medicinal Chemistry ; 13 (2005), 22. - S. 6094-6111deu
dc.identifier.doi10.1016/j.bmc.2005.06.027deu
dc.identifier.pmid16084101
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/14047
dc.language.isoengdeu
dc.legacy.dateIssued2011-12-14deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectsmall moleculedeu
dc.subjectEg5deu
dc.subjectKinesindeu
dc.subject.ddc570deu
dc.titleSynthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5eng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{SunderPlassmann2005-11-15Synth-14047,
  year={2005},
  doi={10.1016/j.bmc.2005.06.027},
  title={Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5},
  number={22},
  volume={13},
  issn={0968-0896},
  journal={Bioorganic & Medicinal Chemistry},
  pages={6094--6111},
  author={Sunder-Plassmann, Nils and Sarli, Vasiliki and Gartner, Michael and Utz, Mathias and Seiler, Jeanette and Huemmer, Stefan and Mayer, Thomas U. and Surrey, Thomas and Giannis, Athanassios}
}
kops.citation.iso690SUNDER-PLASSMANN, Nils, Vasiliki SARLI, Michael GARTNER, Mathias UTZ, Jeanette SEILER, Stefan HUEMMER, Thomas U. MAYER, Thomas SURREY, Athanassios GIANNIS, 2005. Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5. In: Bioorganic & Medicinal Chemistry. 2005, 13(22), pp. 6094-6111. ISSN 0968-0896. Available under: doi: 10.1016/j.bmc.2005.06.027deu
kops.citation.iso690SUNDER-PLASSMANN, Nils, Vasiliki SARLI, Michael GARTNER, Mathias UTZ, Jeanette SEILER, Stefan HUEMMER, Thomas U. MAYER, Thomas SURREY, Athanassios GIANNIS, 2005. Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5. In: Bioorganic & Medicinal Chemistry. 2005, 13(22), pp. 6094-6111. ISSN 0968-0896. Available under: doi: 10.1016/j.bmc.2005.06.027eng
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kops.sourcefieldBioorganic & Medicinal Chemistry. 2005, <b>13</b>(22), pp. 6094-6111. ISSN 0968-0896. Available under: doi: 10.1016/j.bmc.2005.06.027deu
kops.sourcefield.plainBioorganic & Medicinal Chemistry. 2005, 13(22), pp. 6094-6111. ISSN 0968-0896. Available under: doi: 10.1016/j.bmc.2005.06.027deu
kops.sourcefield.plainBioorganic & Medicinal Chemistry. 2005, 13(22), pp. 6094-6111. ISSN 0968-0896. Available under: doi: 10.1016/j.bmc.2005.06.027eng
kops.submitter.emailmarcus.beck@uni-konstanz.dedeu
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