RNA Quadruplexes

Halder, Kangkan; Hartig, Jörg S.

RNA Quadruplexes

Files

Halder_157780.pdf(1.09 MB)

Date

2011

Authors

Halder, Kangkan

Hartig, Jörg S.

Publication type

Contribution to a collection

Published in

Structural and Catalytic Roles of Metal Ions in RNA / Sigel, Astrid; Sigel, Helmut (ed.). - Cambridge : Royal Society of Chemistry, 2011. - (Metal Ions in Life Sciences ; 0). - pp. 125-139. - ISBN 978-1-84973-094-5

Abstract

Opposed to DNA quadruplex sequences, RNA quadruplexes are still less well characterized. On the other hand, RNA quadruplexes are found to be at least as stable as their DNA counterparts. They show the same dependence on metal ions but seem to be much more restricted with respect to the adopted conformations. Other than DNA, which is mostly found to be double-stranded inside cells, RNAs are produced during transcription without its complementary sequence. The absence of a second strand that is able to hybridize and form a duplex makes the folding of RNA quadruplexes a likely event of intramolecular structure formation. Consequently, the formation of RNA quadruplexes in cellular RNAs has recently been suggested and the study of their influence and potential roles in cellular processes has just started. Here we give an overview of the RNA quadruplex field, summarizing issues such as structures, stabilities, and anticipated roles of these interesting four-stranded, guanosine-rich sequences

Subject (DDC)

540 Chemistry

Keywords

gene expression,G-quadruplex,G-quartet,guanosine,potassium,transcription,translation,telomere

Cite This

ISO 690

HALDER, Kangkan, Jörg S. HARTIG, 2011. RNA Quadruplexes. In: SIGEL, Astrid, ed., Helmut SIGEL, ed.. Structural and Catalytic Roles of Metal Ions in RNA. Cambridge:Royal Society of Chemistry, pp. 125-139. ISBN 978-1-84973-094-5. Available under: doi: 10.1039/9781849732512-00125

BibTex

@incollection{Halder2011Quadr-15778,
  year={2011},
  doi={10.1039/9781849732512-00125},
  title={RNA Quadruplexes},
  number={0},
  isbn={978-1-84973-094-5},
  publisher={Royal Society of Chemistry},
  address={Cambridge},
  series={Metal Ions in Life Sciences},
  booktitle={Structural and Catalytic Roles of Metal Ions in RNA},
  pages={125--139},
  editor={Sigel, Astrid and Sigel, Helmut},
  author={Halder, Kangkan and Hartig, Jörg S.}
}

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