Publikation: Commensal microbes and p53 in cancer progression
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2020
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Published
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Biology Direct. BioMed Central. 2020, 15, 25. eISSN 1745-6150. Available under: doi: 10.1186/s13062-020-00281-4
Zusammenfassung
Aetiogenesis of cancer has not been fully determined. Recent advances have clearly defined a role for microenvironmental factors in cancer progression and initiation; in this context, microbiome has recently emerged with a number of reported correlative and causative links implicating alterations of commensal microbes in tumorigenesis. Bacteria appear to have the potential to directly alter physiological pathways of host cells and in specific circumstances, such as the mutation of the tumour suppressive factor p53, they can also directly switch the function of a gene from oncosuppressive to oncogenic. In this minireview, we report a number of examples on how commensal microbes alter the host cell biology, affecting the oncogenic process. We then discuss more in detail how interaction with the gut microbiome can affect the function of p53 mutant in the intestinal tumorigenesis.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Microbiota, p53, Tumour suppression, Oncogenes, Microenvironment
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CELARDO, Ivana, Gerry MELINO, Ivano AMELIO, 2020. Commensal microbes and p53 in cancer progression. In: Biology Direct. BioMed Central. 2020, 15, 25. eISSN 1745-6150. Available under: doi: 10.1186/s13062-020-00281-4BibTex
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title={Commensal microbes and p53 in cancer progression},
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<dcterms:abstract xml:lang="eng">Aetiogenesis of cancer has not been fully determined. Recent advances have clearly defined a role for microenvironmental factors in cancer progression and initiation; in this context, microbiome has recently emerged with a number of reported correlative and causative links implicating alterations of commensal microbes in tumorigenesis. Bacteria appear to have the potential to directly alter physiological pathways of host cells and in specific circumstances, such as the mutation of the tumour suppressive factor p53, they can also directly switch the function of a gene from oncosuppressive to oncogenic. In this minireview, we report a number of examples on how commensal microbes alter the host cell biology, affecting the oncogenic process. We then discuss more in detail how interaction with the gut microbiome can affect the function of p53 mutant in the intestinal tumorigenesis.</dcterms:abstract>
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