Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein

Robotta, Marta; Braun, Patrick; Subramaniam, Vinod; Huber, Martina; Drescher, Malte; Rooijen, Bart D. van

Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein

Dateien

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Datum

2011

Autor:innen

Huber, Martina

Rooijen, Bart D. van

Publikationstyp

Zeitschriftenartikel

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ChemPhysChem. 2011, 12(2), pp. 267-269. ISSN 1439-4235. eISSN 1439-7641. Available under: doi: 10.1002/cphc.201000815

Zusammenfassung

The physiologically relevant conformation of membrane-bound α-Synuclein (αS) can be either a horseshoe or an extended helix structure. Experimental data obtained by site-directed spin labeling in combination with pulsed electron paramagnetic resonance provide compelling evidence of the coexistence of the horseshoe structure and an extended helix of αS bound to a membrane surface, and potentially resolve the debate on the structure of membrane-bound αS.

Fachgebiet (DDC)

540 Chemie

Schlagwörter

electron paramagnetic resonance, membranes, proteins, site-directed spin labeling, vesicles

Zitieren

ISO 690

ROBOTTA, Marta, Patrick BRAUN, Vinod SUBRAMANIAM, Martina HUBER, Malte DRESCHER, Bart D. van ROOIJEN, 2011. Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein. In: ChemPhysChem. 2011, 12(2), pp. 267-269. ISSN 1439-4235. eISSN 1439-7641. Available under: doi: 10.1002/cphc.201000815

BibTex

@article{Robotta2011-02-07Direc-16109,
  year={2011},
  doi={10.1002/cphc.201000815},
  title={Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein},
  number={2},
  volume={12},
  issn={1439-4235},
  journal={ChemPhysChem},
  pages={267--269},
  author={Robotta, Marta and Braun, Patrick and Subramaniam, Vinod and Huber, Martina and Drescher, Malte and Rooijen, Bart D. van}
}

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