Axon-Regenerating Retinal Ganglion Cells in Adult Rats Synthesize the Cell Adhesion Molecule L1 but Not TAG-1 or SC-1

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1997
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Jung, Marion
Petrausch, Barbara
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Retinal ganglion cells (RGCs) in rats regenerate axons in the presence of a PNS nerve graft. To determine if axonregenerating RGCs synthesize cell adhesion/recognition molecules which they possessed during development, retinae were subjected to in situ hybridization with antisense cRNA probes of L1, TAG-1, and SC-1 (and GAP-43 for comparison). L1 and TAG-1 (and GAP-43) proteins on axons were detected with antibodies. L1, TAG-1, and SC-1 (and Gap-43) mRNAs and L1 and TAG-1 (and Gap-43) proteins were expressed by RGCs in embryonic, postnatal, and adult rats. After optic nerve lesion (ONL), the surviving RGCs between 2 and 28 days after ONL continue to express L1. TAG-1 and SC-1 expression, however, is lost. In grafted rats, axon-regenerating RGCs express L1 (together with GAP-43) but neither TAG-1 nor SC-1. Thus, axonal regeneration in grafted rats occurs in the presence of L1 (and GAP-43) but in the absence of TAG-1 and SC-1.

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ISO 690JUNG, Marion, Barbara PETRAUSCH, Claudia STÜRMER, 1997. Axon-Regenerating Retinal Ganglion Cells in Adult Rats Synthesize the Cell Adhesion Molecule L1 but Not TAG-1 or SC-1. In: Molecular and Cellular Neuroscience. 1997, 9(2), pp. 116-131. ISSN 1044-7431. Available under: doi: 10.1006/mcne.1997.0611
BibTex
@article{Jung1997AxonR-8565,
  year={1997},
  doi={10.1006/mcne.1997.0611},
  title={Axon-Regenerating Retinal Ganglion Cells in Adult Rats Synthesize the Cell Adhesion Molecule L1 but Not TAG-1 or SC-1},
  number={2},
  volume={9},
  issn={1044-7431},
  journal={Molecular and Cellular Neuroscience},
  pages={116--131},
  author={Jung, Marion and Petrausch, Barbara and Stürmer, Claudia}
}
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