Solution and implementation of distributed lifespan models

Kurzanzeige
dc.contributor.authorKoch, Gilbert
dc.contributor.authorSchropp, Johannes
dc.date.accessioned2014-03-12T14:14:18Zdeu
dc.date.available2014-03-12T14:14:18Zdeu
dc.date.issued2013-12
dc.description.abstractWe consider a population where every individual has a unique lifespan. After expiring of its lifespan the individual has to leave the population. A realistic approach to describe these lifespans is by a continuous distribution. Such distributed lifespan models (DLSMs) were introduced earlier in the indirect response context and consist of the mathematical convolution operator to describe the rate of change. Therefore, DLSMs could not directly be implemented in standard PKPD software. In this work we present the solution representation of DLSMs with and without a precursor population and an implementation strategy for DLSMs in ADAPT , NONMEM and MATLAB . We fit hemoglobin measurements from literature and investigate computational properties.eng
dc.description.versionpublished
dc.identifier.citationJournal of Pharmacokinetics and Pharmacodynamics ; 40 (2013), 6. - S. 639-650deu
dc.identifier.doi10.1007/s10928-013-9336-ydeu
dc.identifier.pmid24178036
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/26822
dc.language.isoengdeu
dc.legacy.dateIssued2014-03-12deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subject.ddc500deu
dc.titleSolution and implementation of distributed lifespan modelseng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Koch2013-12Solut-26822,
  year={2013},
  doi={10.1007/s10928-013-9336-y},
  title={Solution and implementation of distributed lifespan models},
  number={6},
  volume={40},
  issn={1567-567X},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  pages={639--650},
  author={Koch, Gilbert and Schropp, Johannes}
}
kops.citation.iso690KOCH, Gilbert, Johannes SCHROPP, 2013. Solution and implementation of distributed lifespan models. In: Journal of Pharmacokinetics and Pharmacodynamics. 2013, 40(6), pp. 639-650. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-013-9336-ydeu
kops.citation.iso690KOCH, Gilbert, Johannes SCHROPP, 2013. Solution and implementation of distributed lifespan models. In: Journal of Pharmacokinetics and Pharmacodynamics. 2013, 40(6), pp. 639-650. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-013-9336-yeng
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kops.sourcefieldJournal of Pharmacokinetics and Pharmacodynamics. 2013, <b>40</b>(6), pp. 639-650. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-013-9336-ydeu
kops.sourcefield.plainJournal of Pharmacokinetics and Pharmacodynamics. 2013, 40(6), pp. 639-650. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-013-9336-ydeu
kops.sourcefield.plainJournal of Pharmacokinetics and Pharmacodynamics. 2013, 40(6), pp. 639-650. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-013-9336-yeng
kops.submitter.emailjohannes.schropp@uni-konstanz.dedeu
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