Low vagal tone is associated with impaired post stress recovery of cardiovascular, endocrine, and immune markers

Loading...
Thumbnail Image
Date
2010
Authors
Weber, Cora Stefanie
Thayer, Julian F.
Rudat, Miriam
Zimmermann-Viehoff, Frank
Thomas, Alexander
Perschel, Frank H.
Arck, Petra C.
Deter, Hans C.
Editors
Contact
Journal ISSN
Electronic ISSN
ISBN
Bibliographical data
Publisher
Series
URI (citable link)
DOI (citable link)
ArXiv-ID
International patent number
Link to the license
EU project number
Project
Open Access publication
Collections
Restricted until
Title in another language
Research Projects
Organizational Units
Journal Issue
Publication type
Journal article
Publication status
Published in
European Journal of Applied Physiology ; 109 (2010), 2. - pp. 201-211. - ISSN 1439-6319. - eISSN 1439-6327
Abstract
Reduced heart rate variability (HRV) and delayed blood pressure recovery are associated with increased cardiovascular risk. Besides this evident link, the vagus is thought to play an inhibitory role in the regulation of other allostatic systems, including inflammation and the hypothalamic-pituitary-adrenal (HPA) axis. However, human evidence is scarce. To further explore these associations and with special regard to the postulated mediating role of the vagus, we hypothesised that subjects with low vagal tone as indexed by reduced resting HRV would show impaired post-stress recovery of cardiovascular, endocrine and immune system markers involved in cardiovascular pathology. 44 healthy men underwent a standardised mental stress test. Besides continuous measurement of systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), and HRV serum cortisol, tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were measured before, after, 20, and 60 min after stress. Low versus high HRV groups was defined by median split on resting HRV (RMSSD). The task elicited significant time effects for SBP, DBP, HR, HRV, cortisol, and TNF-alpha. Subjects with low baseline HRV showed almost no modulation of HRV coupled with overall reduced HRV levels, and impaired recovery of DBP, cortisol, and TNF-alpha. Confirming our hypothesis, low vagal tone was associated with impaired recovery of cardiovascular, endocrine, and immune markers in healthy males. The data support an inhibitory role of the vagus in the regulation of allostatic systems as described in the neurovisceral integration model. We posit reduced resting HRV as a risk marker for future cardiovascular and other stress-related disease.
Summary in another language
Subject (DDC)
130 Parapsychology and Occultism
Keywords
Conference
Review
undefined / . - undefined, undefined. - (undefined; undefined)
Cite This
ISO 690WEBER, Cora Stefanie, Julian F. THAYER, Miriam RUDAT, Petra H. WIRTZ, Frank ZIMMERMANN-VIEHOFF, Alexander THOMAS, Frank H. PERSCHEL, Petra C. ARCK, Hans C. DETER, 2010. Low vagal tone is associated with impaired post stress recovery of cardiovascular, endocrine, and immune markers. In: European Journal of Applied Physiology. 109(2), pp. 201-211. ISSN 1439-6319. eISSN 1439-6327. Available under: doi: 10.1007/s00421-009-1341-x
BibTex
@article{Weber2010vagal-30643,
  year={2010},
  doi={10.1007/s00421-009-1341-x},
  title={Low vagal tone is associated with impaired post stress recovery of cardiovascular, endocrine, and immune markers},
  number={2},
  volume={109},
  issn={1439-6319},
  journal={European Journal of Applied Physiology},
  pages={201--211},
  author={Weber, Cora Stefanie and Thayer, Julian F. and Rudat, Miriam and Wirtz, Petra H. and Zimmermann-Viehoff, Frank and Thomas, Alexander and Perschel, Frank H. and Arck, Petra C. and Deter, Hans C.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/30643">
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:creator>Arck, Petra C.</dc:creator>
    <dc:contributor>Deter, Hans C.</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/30643/1/Weber_0-276705.pdf"/>
    <dc:contributor>Thayer, Julian F.</dc:contributor>
    <dcterms:issued>2010</dcterms:issued>
    <dc:creator>Perschel, Frank H.</dc:creator>
    <dc:creator>Deter, Hans C.</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:creator>Zimmermann-Viehoff, Frank</dc:creator>
    <dc:contributor>Thomas, Alexander</dc:contributor>
    <dc:language>eng</dc:language>
    <dcterms:title>Low vagal tone is associated with impaired post stress recovery of cardiovascular, endocrine, and immune markers</dcterms:title>
    <dc:creator>Thomas, Alexander</dc:creator>
    <dc:contributor>Weber, Cora Stefanie</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/30643/1/Weber_0-276705.pdf"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Arck, Petra C.</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-04-01T09:59:31Z</dcterms:available>
    <dcterms:abstract xml:lang="eng">Reduced heart rate variability (HRV) and delayed blood pressure recovery are associated with increased cardiovascular risk. Besides this evident link, the vagus is thought to play an inhibitory role in the regulation of other allostatic systems, including inflammation and the hypothalamic-pituitary-adrenal (HPA) axis. However, human evidence is scarce. To further explore these associations and with special regard to the postulated mediating role of the vagus, we hypothesised that subjects with low vagal tone as indexed by reduced resting HRV would show impaired post-stress recovery of cardiovascular, endocrine and immune system markers involved in cardiovascular pathology. 44 healthy men underwent a standardised mental stress test. Besides continuous measurement of systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), and HRV serum cortisol, tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were measured before, after, 20, and 60 min after stress. Low versus high HRV groups was defined by median split on resting HRV (RMSSD). The task elicited significant time effects for SBP, DBP, HR, HRV, cortisol, and TNF-alpha. Subjects with low baseline HRV showed almost no modulation of HRV coupled with overall reduced HRV levels, and impaired recovery of DBP, cortisol, and TNF-alpha. Confirming our hypothesis, low vagal tone was associated with impaired recovery of cardiovascular, endocrine, and immune markers in healthy males. The data support an inhibitory role of the vagus in the regulation of allostatic systems as described in the neurovisceral integration model. We posit reduced resting HRV as a risk marker for future cardiovascular and other stress-related disease.</dcterms:abstract>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Wirtz, Petra H.</dc:contributor>
    <dc:contributor>Rudat, Miriam</dc:contributor>
    <dc:creator>Weber, Cora Stefanie</dc:creator>
    <dc:creator>Rudat, Miriam</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:contributor>Perschel, Frank H.</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-04-01T09:59:31Z</dc:date>
    <dc:contributor>Zimmermann-Viehoff, Frank</dc:contributor>
    <dc:creator>Wirtz, Petra H.</dc:creator>
    <dc:creator>Thayer, Julian F.</dc:creator>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/30643"/>
  </rdf:Description>
</rdf:RDF>
Internal note
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Contact
URL of original publication
Test date of URL
Examination date of dissertation
Method of financing
Comment on publication
Alliance license
Corresponding Authors der Uni Konstanz vorhanden
International Co-Authors
Bibliography of Konstanz
No
Refereed