Reconsolidation of Human Memory : Brain Mechanisms and Clinical Relevance

Schwabe, Lars; Nader, Karim; Pruessner, Jens C.

Reconsolidation of Human Memory : Brain Mechanisms and Clinical Relevance

Dateien

Schwabe_2-a16e501fuuih9.pdf(127.1 KB)

Datum

2014

Autor:innen

Schwabe, Lars

Nader, Karim

Pruessner, Jens C.

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Biological Psychiatry ; 76 (2014), 4. - S. 274-280. - ISSN 0006-3223. - eISSN 1873-2402

Zusammenfassung

The processes of memory formation and storage are complex and highly dynamic. Once memories are consolidated, they are not necessarily fixed but can be changed long after storage. In particular, seemingly stable memories may re-enter an unstable state when they are retrieved, from which they must be re-stabilized during a process known as reconsolidation. During reconsolidation, memories are susceptible to modifications again, thus providing an opportunity to update seemingly stable memories. While initial demonstrations of memory reconsolidation came mainly from animal studies, evidence for reconsolidation in humans is now accumulating as well. Here, we review recent advances in our understanding of human memory reconsolidation. After a summary of findings on the reconsolidation of human fear and episodic memory, we focus particularly on recent neuroimaging data that provide first insights into how reconsolidation processes are implemented in the human brain. Finally, we discuss the implications of memory modifications during reconsolidation for the treatment of mental disorders such as posttraumatic stress disorder and drug addiction.

Fachgebiet (DDC)

150 Psychologie

Zitieren

ISO 690

SCHWABE, Lars, Karim NADER, Jens C. PRUESSNER, 2014. Reconsolidation of Human Memory : Brain Mechanisms and Clinical Relevance. In: Biological Psychiatry. 76(4), pp. 274-280. ISSN 0006-3223. eISSN 1873-2402. Available under: doi: 10.1016/j.biopsych.2014.03.008

BibTex

@article{Schwabe2014-08Recon-38230,
  year={2014},
  doi={10.1016/j.biopsych.2014.03.008},
  title={Reconsolidation of Human Memory : Brain Mechanisms and Clinical Relevance},
  number={4},
  volume={76},
  issn={0006-3223},
  journal={Biological Psychiatry},
  pages={274--280},
  author={Schwabe, Lars and Nader, Karim and Pruessner, Jens C.}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/38230">
    <dc:contributor>Nader, Karim</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/38230/1/Schwabe_2-a16e501fuuih9.pdf"/>
    <dcterms:issued>2014-08</dcterms:issued>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Schwabe, Lars</dc:creator>
    <dc:creator>Nader, Karim</dc:creator>
    <dc:language>eng</dc:language>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-03-30T09:49:39Z</dcterms:available>
    <dc:contributor>Schwabe, Lars</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-03-30T09:49:39Z</dc:date>
    <dcterms:abstract xml:lang="eng">The processes of memory formation and storage are complex and highly dynamic. Once memories are consolidated, they are not necessarily fixed but can be changed long after storage. In particular, seemingly stable memories may re-enter an unstable state when they are retrieved, from which they must be re-stabilized during a process known as reconsolidation. During reconsolidation, memories are susceptible to modifications again, thus providing an opportunity to update seemingly stable memories. While initial demonstrations of memory reconsolidation came mainly from animal studies, evidence for reconsolidation in humans is now accumulating as well. Here, we review recent advances in our understanding of human memory reconsolidation. After a summary of findings on the reconsolidation of human fear and episodic memory, we focus particularly on recent neuroimaging data that provide first insights into how reconsolidation processes are implemented in the human brain. Finally, we discuss the implications of memory modifications during reconsolidation for the treatment of mental disorders such as posttraumatic stress disorder and drug addiction.</dcterms:abstract>
    <dc:creator>Pruessner, Jens C.</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/38230/1/Schwabe_2-a16e501fuuih9.pdf"/>
    <dc:contributor>Pruessner, Jens C.</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dcterms:title>Reconsolidation of Human Memory : Brain Mechanisms and Clinical Relevance</dcterms:title>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38230"/>
  </rdf:Description>
</rdf:RDF>

Universitätsbibliographie

Nein