Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC)

Schrock, Yvonne; Solis Padilla, Gonzalo; Stürmer, Claudia

Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC)

Dateien

Stuermer_111757.pdfGröße: 2.48 MBDownloads: 719

Datum

2009

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

FEBS Letters. 2009, 583(2), pp. 389-393. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1016/j.febslet.2008.12.038

Zusammenfassung

While the prion protein (PrP) is clearly involved in neuropathology, its physiological roles remain elusive. Here, we demonstrate PrP functions in cell-substrate interaction in Drosophila S2, N2a and HeLa cells. PrP promotes cell spreading and/or filopodia formation when overexpressed, and lamellipodia when downregulated. Moreover, PrP normally accumulates in focal adhesions (FAs), and its downregulation leads to reduced FA numbers, increased FA length, along with Src and focal adhesion kinase (FAK) activation. Furthermore, its overexpression elicits the formation of novel FA-like structures, which require intact reggie/flotillin microdomains. Altogether, PrP modulates process formation and FA dynamics, possibly via signal transduction involving FAK and Src.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

SCHROCK, Yvonne, Gonzalo SOLIS PADILLA, Claudia STÜRMER, 2009. Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC). In: FEBS Letters. 2009, 583(2), pp. 389-393. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1016/j.febslet.2008.12.038

BibTex

@article{Schrock2009Regul-1119,
  year={2009},
  doi={10.1016/j.febslet.2008.12.038},
  title={Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC)},
  number={2},
  volume={583},
  issn={0014-5793},
  journal={FEBS Letters},
  pages={389--393},
  author={Schrock, Yvonne and Solis Padilla, Gonzalo and Stürmer, Claudia}
}

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