New Insights into How Trafficking Regulates T Cell Receptor Signaling

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2016
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Lou, Jieqiong
Deng, Qiji
Pageon, Sophie V.
Gaus, Katharina
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Frontiers in cell and developmental biology. 2016, 4, 77. eISSN 2296-634X. Available under: doi: 10.3389/fcell.2016.00077
Zusammenfassung

There is emerging evidence that exocytosis plays an important role in regulating T cell receptor (TCR) signaling. The trafficking molecules involved in lytic granule (LG) secretion in cytotoxic T lymphocytes (CTL) have been well-studied due to the immune disorder known as familial hemophagocytic lymphohistiocytosis (FHLH). However, the knowledge of trafficking machineries regulating the exocytosis of receptors and signaling molecules remains quite limited. In this review, we summarize the reported trafficking molecules involved in the transport of the TCR and downstream signaling molecules to the cell surface. By combining this information with the known knowledge of LG exocytosis and general exocytic trafficking machinery, we attempt to draw a more complete picture of how the TCR signaling network and exocytic trafficking matrix are interconnected to facilitate T cell activation. This also highlights how membrane compartmentalization facilitates the spatiotemporal organization of cellular responses that are essential for immune functions.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
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TCR signaling, exocytic trafficking, LAT, Rabs, SNAREs
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ISO 690LOU, Jieqiong, Jérémie ROSSY, Qiji DENG, Sophie V. PAGEON, Katharina GAUS, 2016. New Insights into How Trafficking Regulates T Cell Receptor Signaling. In: Frontiers in cell and developmental biology. 2016, 4, 77. eISSN 2296-634X. Available under: doi: 10.3389/fcell.2016.00077
BibTex
@article{Lou2016Insig-42984,
  year={2016},
  doi={10.3389/fcell.2016.00077},
  title={New Insights into How Trafficking Regulates T Cell Receptor Signaling},
  volume={4},
  journal={Frontiers in cell and developmental biology},
  author={Lou, Jieqiong and Rossy, Jérémie and Deng, Qiji and Pageon, Sophie V. and Gaus, Katharina},
  note={Article Number: 77}
}
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