New Insights into How Trafficking Regulates T Cell Receptor Signaling

Lou, Jieqiong; Rossy, Jérémie; Deng, Qiji; Pageon, Sophie V.; Gaus, Katharina

New Insights into How Trafficking Regulates T Cell Receptor Signaling

Files

Lou_2-84aeqj44n6i13.pdf(2.15 MB)

Date

2016

Authors

Lou, Jieqiong

Rossy, Jérémie

Deng, Qiji

Pageon, Sophie V.

Gaus, Katharina

Publication type

Journal article

Publication status

Published

Published in

Frontiers in cell and developmental biology ; 4 (2016). - 77. - eISSN 2296-634X

Abstract

There is emerging evidence that exocytosis plays an important role in regulating T cell receptor (TCR) signaling. The trafficking molecules involved in lytic granule (LG) secretion in cytotoxic T lymphocytes (CTL) have been well-studied due to the immune disorder known as familial hemophagocytic lymphohistiocytosis (FHLH). However, the knowledge of trafficking machineries regulating the exocytosis of receptors and signaling molecules remains quite limited. In this review, we summarize the reported trafficking molecules involved in the transport of the TCR and downstream signaling molecules to the cell surface. By combining this information with the known knowledge of LG exocytosis and general exocytic trafficking machinery, we attempt to draw a more complete picture of how the TCR signaling network and exocytic trafficking matrix are interconnected to facilitate T cell activation. This also highlights how membrane compartmentalization facilitates the spatiotemporal organization of cellular responses that are essential for immune functions.

Subject (DDC)

570 Biosciences, Biology

Keywords

TCR signaling, exocytic trafficking, LAT, Rabs, SNAREs

Cite This

ISO 690

LOU, Jieqiong, Jérémie ROSSY, Qiji DENG, Sophie V. PAGEON, Katharina GAUS, 2016. New Insights into How Trafficking Regulates T Cell Receptor Signaling. In: Frontiers in cell and developmental biology. 4, 77. eISSN 2296-634X. Available under: doi: 10.3389/fcell.2016.00077

BibTex

@article{Lou2016Insig-42984,
  year={2016},
  doi={10.3389/fcell.2016.00077},
  title={New Insights into How Trafficking Regulates T Cell Receptor Signaling},
  volume={4},
  journal={Frontiers in cell and developmental biology},
  author={Lou, Jieqiong and Rossy, Jérémie and Deng, Qiji and Pageon, Sophie V. and Gaus, Katharina},
  note={Article Number: 77}
}

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Refereed

Unknown