@article{Boeck2018-02-27Alter-41788,
  year={2018},
  doi={10.1016/j.jad.2018.02.082},
  title={Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder},
  volume={234},
  issn={0165-0327},
  journal={Journal of Affective Disorders},
  pages={139--147},
  author={Boeck, Christina and Pfister, Sophia and Bürkle, Alexander and Vanhooren, Valerie and Libert, Claude and Salinas-Manrique, Juan and Dietrich, Detlef E. and Kolassa, Iris-Tatjana and Karabatsiakis, Alexander}
}

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    <dcterms:abstract xml:lang="eng">Background&lt;br /&gt;Glycans are short chains of saccharides linked to glycoproteins that are known to be involved in a wide range of inflammatory processes. As depression has been consistently associated with chronic low-grade inflammation, we asked whether patients with Major Depressive Disorder show alterations in the N-glycosylation pattern of serum proteins that might be linked to associated changes in inflammatory processes.&lt;br /&gt;&lt;br /&gt;Methods&lt;br /&gt;In a study cohort of 21 female patients with an acute depressive episode and 21 non-depressed female control subjects aged between 50 and 69 years, we analyzed the serum N-glycan profile by DNA Sequencer Adapted-Fluorophore Assisted Carbohydrate Electrophoresis (DSA-FACE) and assessed the serum levels of interleukin (IL)− 6, tumor necrosis factor (TNF)-α and C-reactive protein (CRP) by chemiluminescence immunoassays and nephelometry.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;Compared to controls, MDD patients showed significant differences in the serum levels of several N-glycan structures. Alterations in the serum N-glycan profile were associated with depressive symptom severity and exploratory analyses revealed that they were most pronounced in MDD patients with a history of childhood sexual abuse. Furthermore, MDD patients showed higher levels of IL-6 and a trend for higher CRP levels, which were also associated with similar alterations in the serum N-glycan profile as those characteristic for MDD patients.&lt;br /&gt;&lt;br /&gt;Limitations&lt;br /&gt;The relatively small sample size and the presence of potential confounders (e.g., BMI, smoking, medication).&lt;br /&gt;&lt;br /&gt;Conclusion&lt;br /&gt;The results offer the first evidence that specific differences in the N-glycosylation pattern of serum proteins constitute a so far unrecognized level of biological alterations that might be involved in the immune changes associated with MDD.</dcterms:abstract>
    <dc:creator>Salinas-Manrique, Juan</dc:creator>
    <dc:contributor>Dietrich, Detlef E.</dc:contributor>
    <dc:language>eng</dc:language>
    <dcterms:issued>2018-02-27</dcterms:issued>
    <dc:contributor>Boeck, Christina</dc:contributor>
    <dc:creator>Boeck, Christina</dc:creator>
    <dc:contributor>Karabatsiakis, Alexander</dc:contributor>
    <dc:contributor>Vanhooren, Valerie</dc:contributor>
    <dc:contributor>Salinas-Manrique, Juan</dc:contributor>
    <dc:contributor>Pfister, Sophia</dc:contributor>
    <dc:creator>Vanhooren, Valerie</dc:creator>
    <dc:creator>Kolassa, Iris-Tatjana</dc:creator>
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    <dc:creator>Dietrich, Detlef E.</dc:creator>
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    <dc:creator>Pfister, Sophia</dc:creator>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-03-15T08:13:16Z</dc:date>
    <dc:creator>Karabatsiakis, Alexander</dc:creator>
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    <dc:creator>Bürkle, Alexander</dc:creator>
    <dc:contributor>Libert, Claude</dc:contributor>
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    <dcterms:title>Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder</dcterms:title>
    <dc:contributor>Bürkle, Alexander</dc:contributor>
    <dc:contributor>Kolassa, Iris-Tatjana</dc:contributor>
    <dc:creator>Libert, Claude</dc:creator>
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