Redox regulation : a new challenge for pharmacology

Frein, Daniel; Schildknecht, Stefan; Bachschmid, Markus; Ullrich, Volker

Redox regulation : a new challenge for pharmacology

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Date

2005

Authors

Frein, Daniel

Schildknecht, Stefan

Bachschmid, Markus

Ullrich, Volker

DOI (citable link)

10.1016/j.bcp.2005.04.012

Collections

Biologie

Publication type

Journal article

Publication status

Published

Published in

Biochemical Pharmacology ; 70 (2005), 6. - pp. 811-823. - ISSN 0006-2952. - eISSN 1873-2968

Abstract

Redox signaling is evolving as a new field of biochemical and pharmacological research. Unlike oxidative stress which is characterized by a macroscopic shift in cellular redox potentials and usually accompanied by oxygen radical induced damage, redox regulation involves subtle and more chemically defined oxidations of short duration. Most important is the reductive component as a necessary part of a reversible regulatory process. Examples of redox regulation occur during early stages of the immune response, in hypoxia or in endothelial dysfunction. Persistent oxidative events together with a decline in the cellular reduction potential lead to oxidative stress as is seen in the pathophysiology of sepsis, reperfusion damage, atherosclerosis and diabetes. Oxidative signals involve superoxide and nitric oxide as the main players which form a system of oxidizing, nitrating or nitrosating species leading to posttranslational modifications of proteins. Modern techniques of immunohistochemistry and mass spectrometry allow a correlation of protein modification, e.g., disulfide, S-oxide, S-nitroso or nitrotyrosine formation, with enzyme activities and cellular responses. In this commentary, examples of the control of prostanoid synthesis by the NO/O2- system are described. Redox regulation represents an interesting challenge for the development of drugs that modulate the oxidative trigger mechanisms or enforce the reductive pathways.

Subject (DDC)

570 Biosciences, Biology

Cite This

ISO 690

FREIN, Daniel, Stefan SCHILDKNECHT, Markus BACHSCHMID, Volker ULLRICH, 2005. Redox regulation : a new challenge for pharmacology. In: Biochemical Pharmacology. 70(6), pp. 811-823. ISSN 0006-2952. eISSN 1873-2968. Available under: doi: 10.1016/j.bcp.2005.04.012

BibTex

@article{Frein2005-09-15Redox-38921,
  year={2005},
  doi={10.1016/j.bcp.2005.04.012},
  title={Redox regulation : a new challenge for pharmacology},
  number={6},
  volume={70},
  issn={0006-2952},
  journal={Biochemical Pharmacology},
  pages={811--823},
  author={Frein, Daniel and Schildknecht, Stefan and Bachschmid, Markus and Ullrich, Volker}
}

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Bibliography of Konstanz

No