Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Data allowing for a complete environmental risk assessment of pharmaceuticals and their photoderatives in the environment are still scarce. In the present study, in vitro toxicity and both bio- and photopersistence of various pharmaceuticals (aciclovir, allopurinol, cetirizine, cimetidine, fluconazole, hydrochlorothiazide, lisinopril, phenytoin, primidone, ranitidine, sotalol, sulpiride, tramadol and valsartane) as well as their phototransformation products were evaluated in order to fill data gaps and to help prioritise them for further testing. Twelve out of the fourteen compounds investigated were found to be neither readily nor inherently biodegradable in the Organisation of Economic Cooperation and Development-biodegradability tests. The study further demonstrates that the photo-induced transformation of the pharmaceuticals was faster upon irradiation with a Hg lamp (UV light) than with a Xe lamp emitting a spectrum that mimics sunlight. Comparing the non-irradiated with the respective irradiated solutions, a higher acute and chronic toxicity against bacteria was found for the irradiated solutions of seven compounds (cetirizine, cimetidine, hydrochlorothiazide, ranitidine, sulpiride, tramadol and valsartane). No cyto- and genotoxic effects were found in human cervical (HeLa) and liver (Hep-G2) cells for any of the investigated compounds or their phototransformation products. This comparative study documents that phototransformation products can arise as a result of UV treatment of wastewater containing these pharmaceuticals. It further demonstrates that some phototransformation products may have a higher environmental risk potential than the respective parent compounds because some phototransformation products exhibited a higher bacterial toxicity.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
BERGHEIM, Marlies, Richard GMINSKI, Bernd SPANGENBERG, Malgorzata DEBIAK, Alexander BÜRKLE, Volker MERSCH-SUNDERMANN, Klaus KÜMMERER, Reto GIERÉ, 2014. Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity. In: Environmental Chemistry. 2014, 11(4), pp. 431-444. ISSN 1448-2517. eISSN 1449-8979. Available under: doi: 10.1071/EN13218BibTex
@article{Bergheim2014Recal-29559, year={2014}, doi={10.1071/EN13218}, title={Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity}, number={4}, volume={11}, issn={1448-2517}, journal={Environmental Chemistry}, pages={431--444}, author={Bergheim, Marlies and Gminski, Richard and Spangenberg, Bernd and Debiak, Malgorzata and Bürkle, Alexander and Mersch-Sundermann, Volker and Kümmerer, Klaus and Gieré, Reto} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29559"> <dcterms:title>Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity</dcterms:title> <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights> <dc:creator>Spangenberg, Bernd</dc:creator> <dc:contributor>Spangenberg, Bernd</dc:contributor> <dc:creator>Gieré, Reto</dc:creator> <dc:creator>Debiak, Malgorzata</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/29559/1/Bergheim_0-265718.pdf"/> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/4.0/"/> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/> <dc:creator>Kümmerer, Klaus</dc:creator> <dc:creator>Bürkle, Alexander</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/29559/1/Bergheim_0-265718.pdf"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-01-21T08:12:52Z</dc:date> <dc:contributor>Gminski, Richard</dc:contributor> <dcterms:issued>2014</dcterms:issued> <dc:creator>Bergheim, Marlies</dc:creator> <dc:contributor>Kümmerer, Klaus</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/29559"/> <dc:contributor>Debiak, Malgorzata</dc:contributor> <dc:creator>Gminski, Richard</dc:creator> <dc:contributor>Gieré, Reto</dc:contributor> <dc:contributor>Mersch-Sundermann, Volker</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Mersch-Sundermann, Volker</dc:creator> <dcterms:abstract xml:lang="eng">Data allowing for a complete environmental risk assessment of pharmaceuticals and their photoderatives in the environment are still scarce. In the present study, in vitro toxicity and both bio- and photopersistence of various pharmaceuticals (aciclovir, allopurinol, cetirizine, cimetidine, fluconazole, hydrochlorothiazide, lisinopril, phenytoin, primidone, ranitidine, sotalol, sulpiride, tramadol and valsartane) as well as their phototransformation products were evaluated in order to fill data gaps and to help prioritise them for further testing. Twelve out of the fourteen compounds investigated were found to be neither readily nor inherently biodegradable in the Organisation of Economic Cooperation and Development-biodegradability tests. The study further demonstrates that the photo-induced transformation of the pharmaceuticals was faster upon irradiation with a Hg lamp (UV light) than with a Xe lamp emitting a spectrum that mimics sunlight. Comparing the non-irradiated with the respective irradiated solutions, a higher acute and chronic toxicity against bacteria was found for the irradiated solutions of seven compounds (cetirizine, cimetidine, hydrochlorothiazide, ranitidine, sulpiride, tramadol and valsartane). No cyto- and genotoxic effects were found in human cervical (HeLa) and liver (Hep-G2) cells for any of the investigated compounds or their phototransformation products. This comparative study documents that phototransformation products can arise as a result of UV treatment of wastewater containing these pharmaceuticals. It further demonstrates that some phototransformation products may have a higher environmental risk potential than the respective parent compounds because some phototransformation products exhibited a higher bacterial toxicity.</dcterms:abstract> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-01-21T08:12:52Z</dcterms:available> <dc:contributor>Bergheim, Marlies</dc:contributor> <dc:contributor>Bürkle, Alexander</dc:contributor> </rdf:Description> </rdf:RDF>