Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2014
Autor:innen
Bergheim, Marlies
Gminski, Richard
Spangenberg, Bernd
Mersch-Sundermann, Volker
Kümmerer, Klaus
Gieré, Reto
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Gold
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Environmental Chemistry. 2014, 11(4), pp. 431-444. ISSN 1448-2517. eISSN 1449-8979. Available under: doi: 10.1071/EN13218
Zusammenfassung

Data allowing for a complete environmental risk assessment of pharmaceuticals and their photoderatives in the environment are still scarce. In the present study, in vitro toxicity and both bio- and photopersistence of various pharmaceuticals (aciclovir, allopurinol, cetirizine, cimetidine, fluconazole, hydrochlorothiazide, lisinopril, phenytoin, primidone, ranitidine, sotalol, sulpiride, tramadol and valsartane) as well as their phototransformation products were evaluated in order to fill data gaps and to help prioritise them for further testing. Twelve out of the fourteen compounds investigated were found to be neither readily nor inherently biodegradable in the Organisation of Economic Cooperation and Development-biodegradability tests. The study further demonstrates that the photo-induced transformation of the pharmaceuticals was faster upon irradiation with a Hg lamp (UV light) than with a Xe lamp emitting a spectrum that mimics sunlight. Comparing the non-irradiated with the respective irradiated solutions, a higher acute and chronic toxicity against bacteria was found for the irradiated solutions of seven compounds (cetirizine, cimetidine, hydrochlorothiazide, ranitidine, sulpiride, tramadol and valsartane). No cyto- and genotoxic effects were found in human cervical (HeLa) and liver (Hep-G2) cells for any of the investigated compounds or their phototransformation products. This comparative study documents that phototransformation products can arise as a result of UV treatment of wastewater containing these pharmaceuticals. It further demonstrates that some phototransformation products may have a higher environmental risk potential than the respective parent compounds because some phototransformation products exhibited a higher bacterial toxicity.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
540 Chemie
Schlagwörter
biodegradation, HeLa cells, Hep-G2 cells, irradiation, predicted environmental concentrations (PECs), UV, Vibrio fischeri.
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690BERGHEIM, Marlies, Richard GMINSKI, Bernd SPANGENBERG, Malgorzata DEBIAK, Alexander BÜRKLE, Volker MERSCH-SUNDERMANN, Klaus KÜMMERER, Reto GIERÉ, 2014. Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity. In: Environmental Chemistry. 2014, 11(4), pp. 431-444. ISSN 1448-2517. eISSN 1449-8979. Available under: doi: 10.1071/EN13218
BibTex
@article{Bergheim2014Recal-29559,
  year={2014},
  doi={10.1071/EN13218},
  title={Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity},
  number={4},
  volume={11},
  issn={1448-2517},
  journal={Environmental Chemistry},
  pages={431--444},
  author={Bergheim, Marlies and Gminski, Richard and Spangenberg, Bernd and Debiak, Malgorzata and Bürkle, Alexander and Mersch-Sundermann, Volker and Kümmerer, Klaus and Gieré, Reto}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29559">
    <dcterms:title>Recalcitrant pharmaceuticals in the aquatic environment : a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity</dcterms:title>
    <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights>
    <dc:creator>Spangenberg, Bernd</dc:creator>
    <dc:contributor>Spangenberg, Bernd</dc:contributor>
    <dc:creator>Gieré, Reto</dc:creator>
    <dc:creator>Debiak, Malgorzata</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/29559/1/Bergheim_0-265718.pdf"/>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/4.0/"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:creator>Kümmerer, Klaus</dc:creator>
    <dc:creator>Bürkle, Alexander</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/29559/1/Bergheim_0-265718.pdf"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-01-21T08:12:52Z</dc:date>
    <dc:contributor>Gminski, Richard</dc:contributor>
    <dcterms:issued>2014</dcterms:issued>
    <dc:creator>Bergheim, Marlies</dc:creator>
    <dc:contributor>Kümmerer, Klaus</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/29559"/>
    <dc:contributor>Debiak, Malgorzata</dc:contributor>
    <dc:creator>Gminski, Richard</dc:creator>
    <dc:contributor>Gieré, Reto</dc:contributor>
    <dc:contributor>Mersch-Sundermann, Volker</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:creator>Mersch-Sundermann, Volker</dc:creator>
    <dcterms:abstract xml:lang="eng">Data allowing for a complete environmental risk assessment of pharmaceuticals and their photoderatives in the environment are still scarce. In the present study, in vitro toxicity and both bio- and photopersistence of various pharmaceuticals (aciclovir, allopurinol, cetirizine, cimetidine, fluconazole, hydrochlorothiazide, lisinopril, phenytoin, primidone, ranitidine, sotalol, sulpiride, tramadol and valsartane) as well as their phototransformation products were evaluated in order to fill data gaps and to help prioritise them for further testing. Twelve out of the fourteen compounds investigated were found to be neither readily nor inherently biodegradable in the Organisation of Economic Cooperation and Development-biodegradability tests. The study further demonstrates that the photo-induced transformation of the pharmaceuticals was faster upon irradiation with a Hg lamp (UV light) than with a Xe lamp emitting a spectrum that mimics sunlight. Comparing the non-irradiated with the respective irradiated solutions, a higher acute and chronic toxicity against bacteria was found for the irradiated solutions of seven compounds (cetirizine, cimetidine, hydrochlorothiazide, ranitidine, sulpiride, tramadol and valsartane). No cyto- and genotoxic effects were found in human cervical (HeLa) and liver (Hep-G2) cells for any of the investigated compounds or their phototransformation products. This comparative study documents that phototransformation products can arise as a result of UV treatment of wastewater containing these pharmaceuticals. It further demonstrates that some phototransformation products may have a higher environmental risk potential than the respective parent compounds because some phototransformation products exhibited a higher bacterial toxicity.</dcterms:abstract>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-01-21T08:12:52Z</dcterms:available>
    <dc:contributor>Bergheim, Marlies</dc:contributor>
    <dc:contributor>Bürkle, Alexander</dc:contributor>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen