@article{DeFrancesco2019peopl-44505,
  year={2019},
  doi={10.1097/QAD.0000000000002063},
  title={Do people living with HIV experience greater age advancement than their HIV-negative counterparts?},
  number={2},
  volume={33},
  issn={0269-9370},
  journal={AIDS},
  pages={259--268},
  author={De Francesco, Davide and Wit, Ferdinand W. and Bürkle, Alexander and Oehlke, Sebastian and Kootstra, Neeltje A. and Winston, Alan and Franceschi, Claudio and Garagnani, Paolo and Pirazzini, Chiara and Libert, Claude}
}

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/44505">
    <dc:contributor>Franceschi, Claudio</dc:contributor>
    <dc:contributor>Oehlke, Sebastian</dc:contributor>
    <dcterms:issued>2019</dcterms:issued>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-01-09T14:47:44Z</dc:date>
    <dc:creator>Kootstra, Neeltje A.</dc:creator>
    <dc:creator>Bürkle, Alexander</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Libert, Claude</dc:contributor>
    <dc:contributor>Kootstra, Neeltje A.</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Oehlke, Sebastian</dc:creator>
    <dcterms:title>Do people living with HIV experience greater age advancement than their HIV-negative counterparts?</dcterms:title>
    <dc:creator>Franceschi, Claudio</dc:creator>
    <dc:contributor>Garagnani, Paolo</dc:contributor>
    <dc:contributor>Wit, Ferdinand W.</dc:contributor>
    <dc:language>eng</dc:language>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/44505/1/DeFrancesco_2-2m7ct271nlt92.pdf"/>
    <dc:creator>De Francesco, Davide</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/44505"/>
    <dc:creator>Garagnani, Paolo</dc:creator>
    <dc:contributor>De Francesco, Davide</dc:contributor>
    <dc:creator>Pirazzini, Chiara</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-01-09T14:47:44Z</dcterms:available>
    <dcterms:abstract xml:lang="eng">Objectives: Despite successful antiretroviral (ARV) therapy, people living with HIV (PLWH) may show signs of premature/accentuated aging. We compared established biomarkers of aging in PLWH, appropriately-chosen HIV-negative individuals, and blood donors, and explored factors associated with biological age advancement.&lt;br /&gt;&lt;br /&gt;Design: Cross-sectional analysis of 134 PLWH on suppressive ARV therapy, 79 lifestyle-comparable HIV-negative controls aged ≥45 years from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors (BD).&lt;br /&gt;&lt;br /&gt;Methods: Biological age was estimated using a validated algorithm based on ten biomarkers. Associations between ‘age advancement’ (biological minus chronological age) and HIV status/parameters, lifestyle, cytomegalovirus (CMV), hepatitis B (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression.&lt;br /&gt;&lt;br /&gt;Results: The average (95% CI) age advancement was greater in both HIV-positive [13.2 (11.6, 14.9) years] and HIV-negative [5.5 (3.8, 7.2) years] COBRA participants compared to BD [-7.0 (-4.1, -9.9) years, both p's &lt; 0.001)], but also in HIV-positive compared to HIV-negative participants (p &lt; 0.001). Chronic HBV, higher anti-CMV IgG titer and CD8&lt;sup&gt;+&lt;/sup&gt; T-cell count were each associated with increased age advancement, independently of HIV-status/group. Among HIV-positive participants, age advancement was increased by 3.5 (0.1, 6.8) years among those with nadir CD4&lt;sup&gt;+&lt;/sup&gt; &lt; 200 cells/μL and by 0.1 (0.06, 0.2) years for each additional month of exposure to saquinavir.&lt;br /&gt;&lt;br /&gt;Conclusions: Both treated PLWH and lifestyle-comparable HIV-negative individuals show signs of age advancement compared to BD, to which persistent CMV, HBV co-infection and CD8&lt;sup&gt;+&lt;/sup&gt; T-cell activation may have contributed. Age advancement remained greatest in PLWH and was related to prior immunodeficiency and cumulative saquinavir exposure.</dcterms:abstract>
    <dc:contributor>Pirazzini, Chiara</dc:contributor>
    <dc:creator>Winston, Alan</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Libert, Claude</dc:creator>
    <dc:contributor>Bürkle, Alexander</dc:contributor>
    <dc:creator>Wit, Ferdinand W.</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/44505/1/DeFrancesco_2-2m7ct271nlt92.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Winston, Alan</dc:contributor>
  </rdf:Description>
</rdf:RDF>