@article{Rauh2005-10-13Calci-14045,
  year={2005},
  doi={10.1038/nature04093},
  title={Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation},
  number={7061},
  volume={437},
  issn={0028-0836},
  journal={Nature},
  pages={1048--1052},
  author={Rauh, Nadine R. and Schmidt, Andreas and Bormann, Jenny and Nigg, Erich A. and Mayer, Thomas U.}
}

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    <dc:contributor>Mayer, Thomas U.</dc:contributor>
    <dcterms:bibliographicCitation>Nature ; 437 (2005), 7061. - S. 1048-1052</dcterms:bibliographicCitation>
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    <dc:contributor>Bormann, Jenny</dc:contributor>
    <dcterms:abstract xml:lang="eng">Vertebrate eggs awaiting fertilization are arrested at metaphase of meiosis II by a biochemical activity termed cytostatic factor (CSF). This activity inhibits the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that triggers anaphase onset and mitotic/meiotic exit by targeting securin and M-phase cyclins for destruction. On fertilization a transient rise in free intracellular calcium causes release from CSF arrest and thus APC/C activation. Although it has previously been shown that calcium induces the release of APC/C from CSF inhibition through calmodulin-dependent protein kinase II (CaMKII), the relevant substrates of this kinase have not been identified. Recently, we characterized XErp1 (Emi2), an inhibitor of the APC/C and key component of CSF activity in Xenopus egg extract. Here we show that calcium-activated CaMKII triggers exit from meiosis II by sensitizing the APC/C inhibitor XErp1 for polo-like kinase 1 (Plx1)-dependent degradation. Phosphorylation of XErp1 by CaMKII leads to the recruitment of Plx1 that in turn triggers the destruction of XErp1 by phosphorylating a site known to serve as a phosphorylation-dependent degradation signal. These results provide a molecular explanation for how the fertilization-induced calcium increase triggers exit from meiosis II.</dcterms:abstract>
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    <dc:contributor>Nigg, Erich A.</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Rauh, Nadine R.</dc:contributor>
    <dc:creator>Bormann, Jenny</dc:creator>
    <dc:creator>Schmidt, Andreas</dc:creator>
    <dc:creator>Nigg, Erich A.</dc:creator>
    <dcterms:issued>2005-10-13</dcterms:issued>
    <dc:contributor>Schmidt, Andreas</dc:contributor>
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    <dcterms:title>Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation</dcterms:title>
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    <dc:creator>Mayer, Thomas U.</dc:creator>
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    <dc:creator>Rauh, Nadine R.</dc:creator>
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