Synthese und Screening von Multivalenten Lektinliganden

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SPECKER, Daniel, 2008. Synthese und Screening von Multivalenten Lektinliganden [Dissertation]. Konstanz: University of Konstanz

@phdthesis{Specker2008Synth-9961, title={Synthese und Screening von Multivalenten Lektinliganden}, year={2008}, author={Specker, Daniel}, address={Konstanz}, school={Universität Konstanz} }

terms-of-use 2011-03-24T18:15:35Z The selective synthesis of alpha and beta carbohydrate carbonates is reported. By reaction of these carbonates with amino-functionalised scaffolds, multivalent lectin ligands were obtained and have been tested in vitro and in vivo.<br />Two Split-Mix libraries, consisting of 13500 cyclic glycopeptides, were obtained by combinatorial solid phase peptide synthesis. By screening of these libraries potent ligands for the lectin Viscum album agglutinin were identified using the Edman-degredation.<br />Selected ligands were resynthesized and tested in solution. 2011-03-24T18:15:35Z Synthese und Screening von Multivalenten Lektinliganden Synthesis and Screening of Multivalent Lectin Ligands application/pdf Specker, Daniel Specker, Daniel deu 2008

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