Synthesis and Application of Glycopeptide and Glycoprotein Mimetics


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SPECKER, Daniel, Valentin WITTMANN, 2007. Synthesis and Application of Glycopeptide and Glycoprotein Mimetics. In: Topics in Current Chemistry. 267, pp. 65-107. Available under: doi: 10.1007/128_2006_104

@article{Specker2007Synth-9957, title={Synthesis and Application of Glycopeptide and Glycoprotein Mimetics}, year={2007}, doi={10.1007/128_2006_104}, volume={267}, journal={Topics in Current Chemistry}, pages={65--107}, author={Specker, Daniel and Wittmann, Valentin} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:isPartOf rdf:resource=""/> <dc:rights>terms-of-use</dc:rights> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:language>eng</dc:language> <dc:date rdf:datatype="">2011-03-24T18:15:34Z</dc:date> <dspace:hasBitstream rdf:resource=""/> <dc:creator>Wittmann, Valentin</dc:creator> <dcterms:bibliographicCitation>First publ. in: Topics in Current Chemistry 267 (2007), pp. 65-107</dcterms:bibliographicCitation> <bibo:uri rdf:resource=""/> <dc:format>application/pdf</dc:format> <dc:contributor>Wittmann, Valentin</dc:contributor> <dcterms:issued>2007</dcterms:issued> <dcterms:title>Synthesis and Application of Glycopeptide and Glycoprotein Mimetics</dcterms:title> <dc:contributor>Specker, Daniel</dc:contributor> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:rights rdf:resource=""/> <dc:creator>Specker, Daniel</dc:creator> <dcterms:hasPart rdf:resource=""/> <dcterms:available rdf:datatype="">2011-03-24T18:15:34Z</dcterms:available> <dcterms:abstract xml:lang="eng">Glycosylation of proteins is the most complex form of posttranslational modification. Glycan chains of glycoproteins are involved in numerous biological recognition events, such as protein folding, cell cell communication and adhesion, cell growth and differentiation, as well as bacterial and viral infection. As an alternative to glycoprotein synthesis, approaches to the construction of glycopeptide and glycoprotein mimetics have been developed. These so-called neoglycopeptides and neoglycoproteins, respectively, provide insight on the importance of distinct structural elements on biological activity. Furthermore, they may have improved properties, such as increased stability in the case of S- and C-glycopeptides. This article summarizes recent progress in the field of synthetic glycosylated amino acids, peptides, and proteins with non-natural structural elements with a focus on the carbohydrate peptide linkage. Linear and convergent approaches are discussed. Application of chemoselective ligation reactions provides access to pure glycoforms of glycoprotein mimetics.</dcterms:abstract> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> </rdf:Description> </rdf:RDF>

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