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Site Specific Identification of N-Linked Glycosylation in Proteins by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

Site Specific Identification of N-Linked Glycosylation in Proteins by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

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PERDIVARA, Irina, Roxana Elena IACOB, Michael PRZYBYLSKI, Kenneth B. TOMER, 2008. Site Specific Identification of N-Linked Glycosylation in Proteins by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry. In: POPESCU, Crisan, ed. and others. Applications of Mass Spectrometry in Life Safety. Dordrecht:Springer, pp. 109-120

@incollection{Perdivara2008Speci-9923, title={Site Specific Identification of N-Linked Glycosylation in Proteins by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry}, year={2008}, address={Dordrecht}, publisher={Springer}, booktitle={Applications of Mass Spectrometry in Life Safety}, pages={109--120}, editor={Popescu, Crisan}, author={Perdivara, Irina and Iacob, Roxana Elena and Przybylski, Michael and Tomer, Kenneth B.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/9923"> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:format>application/pdf</dc:format> <dcterms:bibliographicCitation>First publ. in: Applications of Mass Spectrometry in Life Safety / ed. by Crisan Popescu ... Dordrecht: Springer, 2008, pp. 109-120</dcterms:bibliographicCitation> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:15:20Z</dc:date> <dc:contributor>Iacob, Roxana Elena</dc:contributor> <dc:creator>Iacob, Roxana Elena</dc:creator> <dcterms:abstract xml:lang="eng">Recently, we reported the characterization of the glycans attached at the 11 N-glycosylation sites of Hepatitis C virus E2 envelope glycoprotein by tandem mass spectrometry. Infections caused by Hepatitis C virus represent the main cause of liver diseases such as hepatitis, cirrhosis and hepatocellular carcinoma. The N-linked sugars consist primarily of high mannose glycans, with structures ranging from the minimal core structure, Man3GlcNAc2 (Man3) up to 12 hexose residues attached to the GlcNAc-ß(l 4)-GlcNAc core (depicted as Hex3Man9GlcNAc2). Furthermore, the site N41 (N423) was observed to contain complex type glycans with the structures Man3-GlcNAc and Man3-GlcNAcFuc, in addition to the high mannose population Man3 through Man6, while the site N48 (N430) was occupied exclusively with complex type glycans (Man3-Fuc, Man3-GlcNAcFuc and Man3-GlcNAc2Fuc). The present contribution summarizes our experimental observations upon the factors which may have an impact on the CID tandem mass spectra of glycopeptides.</dcterms:abstract> <dc:creator>Tomer, Kenneth B.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:15:20Z</dcterms:available> <dc:rights>deposit-license</dc:rights> <dc:language>eng</dc:language> <dcterms:issued>2008</dcterms:issued> <dc:creator>Perdivara, Irina</dc:creator> <dc:contributor>Przybylski, Michael</dc:contributor> <dc:creator>Przybylski, Michael</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/9923"/> <dc:contributor>Perdivara, Irina</dc:contributor> <dcterms:title>Site Specific Identification of N-Linked Glycosylation in Proteins by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry</dcterms:title> <dc:contributor>Tomer, Kenneth B.</dc:contributor> </rdf:Description> </rdf:RDF>

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