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Cytotoxic Titanium Salan Complexes : Surprising Interaction of Salan and Alkoxy Ligands

Cytotoxic Titanium Salan Complexes : Surprising Interaction of Salan and Alkoxy Ligands

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IMMEL, Timo, Ulrich GROTH, Thomas HUHN, 2010. Cytotoxic Titanium Salan Complexes : Surprising Interaction of Salan and Alkoxy Ligands. In: Chemistry: a European Journal. 16(9), pp. 2775-2789. eISSN 0947-6539. Available under: doi: 10.1002/chem.200902312

@article{Immel2010Cytot-9908, title={Cytotoxic Titanium Salan Complexes : Surprising Interaction of Salan and Alkoxy Ligands}, year={2010}, doi={10.1002/chem.200902312}, number={9}, volume={16}, journal={Chemistry: a European Journal}, pages={2775--2789}, author={Immel, Timo and Groth, Ulrich and Huhn, Thomas} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/9908"> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Groth, Ulrich</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:15:14Z</dc:date> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/9908"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:15:14Z</dcterms:available> <dcterms:abstract xml:lang="eng">The synthesis, biochemical evaluation, and hydrolysis studies of a wide selection of alkyl- and halogen-substituted titanium salan alkoxides are presented herein. A systematic change in the employed alkoxides revealed that both the bulk of the salan ligands and the steric demand of the labile ligands are of great importance for the obtained biological activity. Surprisingly, these two factors are not independent from each other; lowering the steric demand of the alkoxide of a hitherto nontoxic complex renders it cytotoxic. Therefore, our data suggest that the overall size of the complex exerts a strong influence on its biological activity. To decide whether the correlation between the cytotoxicity and the steric demand of the whole complex is merely based on an altered hydrolysis or on the interaction with biomolecules, the behavior of selected complexes under hydrolytic conditions and the influence of transferrin were investigated. Complexes differing only in their labile alkoxy ligands gave the same hydrolysis products with similar hydrolysis rates but displayed cytotoxicities that differed in the range of one order of magnitude. Thus, it seems that the hydrolysis product is not the active species but rather that the unhydrolysed complex is important for the first interaction with a biomolecule. This promoted the idea of hydrolysis being a detoxification pathway. In accordance with the above conclusion, chloro-substituted complex [Ti(PhClNMe)2(OiPr)2] displayed a high cytotoxicity (IC50≈5 μM) and surprisingly high hydrolytic stability (t1/2=108  h). These findings, together with the observed cytotoxicity in a cisplatin-resistant cell line, make halo-substituted salan complexes an interesting target for further studies.</dcterms:abstract> <dc:language>eng</dc:language> <dc:rights>deposit-license</dc:rights> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dcterms:bibliographicCitation>First publ. in: Chemistry: a European Journal 16 (2010), 9, pp. 2775-2789</dcterms:bibliographicCitation> <dc:format>application/pdf</dc:format> <dcterms:issued>2010</dcterms:issued> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9908/1/17_Chem.Eur.J.2010.pdf"/> <dc:creator>Huhn, Thomas</dc:creator> <dc:contributor>Huhn, Thomas</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dcterms:title>Cytotoxic Titanium Salan Complexes : Surprising Interaction of Salan and Alkoxy Ligands</dcterms:title> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9908/1/17_Chem.Eur.J.2010.pdf"/> <dc:creator>Immel, Timo</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:contributor>Immel, Timo</dc:contributor> <dc:contributor>Groth, Ulrich</dc:contributor> </rdf:Description> </rdf:RDF>

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