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Chemoenzymatic Synthesis and Fluorescent Visualization of Cell-Surface Selectin-Bound Sialyl Lewis X Derivatives

Chemoenzymatic Synthesis and Fluorescent Visualization of Cell-Surface Selectin-Bound Sialyl Lewis X Derivatives

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WITTMANN, Valentin, Arun K. DATTA, Kathryn M. KOELLER, Chi-Huey WONG, 2000. Chemoenzymatic Synthesis and Fluorescent Visualization of Cell-Surface Selectin-Bound Sialyl Lewis X Derivatives. In: Chemistry - A European Journal. 6(1), pp. 162-171. ISSN 0947-6539. eISSN 1521-3765

@article{Wittmann2000Chemo-9811, title={Chemoenzymatic Synthesis and Fluorescent Visualization of Cell-Surface Selectin-Bound Sialyl Lewis X Derivatives}, year={2000}, number={1}, volume={6}, issn={0947-6539}, journal={Chemistry - A European Journal}, pages={162--171}, author={Wittmann, Valentin and Datta, Arun K. and Koeller, Kathryn M. and Wong, Chi-Huey} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/9811"> <dcterms:bibliographicCitation>First publ. in: Chemistry - A European Journal 6 (2000), 1, pp. 162-171</dcterms:bibliographicCitation> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:rights>deposit-license</dc:rights> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:14:34Z</dc:date> <dc:creator>Datta, Arun K.</dc:creator> <dc:contributor>Datta, Arun K.</dc:contributor> <dc:creator>Koeller, Kathryn M.</dc:creator> <dc:contributor>Koeller, Kathryn M.</dc:contributor> <dc:creator>Wong, Chi-Huey</dc:creator> <dcterms:title>Chemoenzymatic Synthesis and Fluorescent Visualization of Cell-Surface Selectin-Bound Sialyl Lewis X Derivatives</dcterms:title> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9811/1/Chemoenzymatic_Synthesis.pdf"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:14:34Z</dcterms:available> <dc:creator>Wittmann, Valentin</dc:creator> <dc:contributor>Wittmann, Valentin</dc:contributor> <dc:contributor>Wong, Chi-Huey</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9811/1/Chemoenzymatic_Synthesis.pdf"/> <dcterms:abstract xml:lang="eng">Sialyl Lewis x (sLex) derivatives conjugated to readily visualized molecular labels are useful chemical probes to study selectin-carbohydrate interactions. Localization of the selectins on the surface of leukocytes and activated endothelial cells can be detected through fluorescence of bound selectin ligands. Herein we present a short chemoenzymatic synthesis of a fluorescently labeled bivalent sLe× conjugate. The use of an amino-substituted monovalent sLe× to obtain fluorescent- and biotin-labeled sLe× derivatives is also described. The cell-staining utility of the fluorescent sLe× conjugates is demonstrated for a HUVEC cell line expressing E-selectin and for CHO-K1 cells expressing either L- or E-selectin.</dcterms:abstract> <dc:language>eng</dc:language> <dcterms:issued>2000</dcterms:issued> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/9811"/> <dc:format>application/pdf</dc:format> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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